岳章显 刘汉珍

[摘要]目的：观察角膜缘干细胞移植联合丝裂霉素C及羊膜移植治疗复发性翼状胬肉的美容效果。方法：选择复发性翼状胬肉患者46例53眼，在显微镜下行复发性翼状胬肉切除、角膜缘干细胞移植联合丝裂霉素C及羊膜移植，术后观察3～24个月。结果：本组共46例53眼，51眼术后舒适，角膜、结膜面光滑平整，表面无充血，无新生血管及翼状胬肉组织再复发，眼部美观改善，复发2眼，复发率为3.77%。结论：角膜缘干细胞移植联合丝裂霉素C及羊膜移植治疗复发性翼状胬肉再复发率低，创面修复好，安全可靠，眼部美容效果好。

[关键词]角膜缘干细胞移植；丝裂霉素C；羊膜移植；复发性胬肉

[中图分类号]R622 [文献标志码]A [文章编号]1008-6455（2018）09-0077-03

The Aesthetic Effect of Limbal Stem Cell Transplantation Combined with Mitomycin C （MMC） and Amniotic Membrane Transplantation for Recurrent Pterygium

YUE Zhang-xian1，LIU Han-zhen2

（1.Department of Ophthalmology；2.Department of Stomatology，Central Hospital of Xiaogan，Xiaogan 432000，Hubei，China）

Abstract： Objective To observe the cosmetic effect of limbal stem cell transplantation with mitomycin C（MMC） and amniotic membrane transplantation for recurrent pterygium. Methods Forty-six cases with recurrent pterygium were collected. The recurrent pterygium was dissected under the microscope. The dissected area was applied with limbal stem cell transplantation and mitomycin C and amniotic membrane transplantation. We had postoperative follow-up from three months to two years. Results There were 46 cases（53 eyes）. Postoperative comfort，smooth and smooth corneal and conjunctival surfaces， no congestion， no recurrence of neovascularization and pterygium， and improvement of eye aesthetics were observed in 51 eyes. The recurrence rate was 3.77%（2/53）. Conclusion Limbal stem cell transplantation with mitomycin C（MMC） and amniotic membrane transplantation had good result for recurrent pterygium.Wound recovery was good.Recurrence rate was low. The method was reliable.

Key words： limbal stem cell transplantation； mitomycin C； amniotic membrane transplantation； recurrent pterygium

翼狀胬肉切除术后复发在临床非常多见，如果病情发展到一定程度可诱发散光、视力下降、睑球粘连、干眼症、眼球刺激征等一系列临床症状[1-2]，严重影响到患者的视功能和眼部外观，而且，复发翼状胬肉下的角膜和巩膜部容易形成更多的瘢痕[3]，改进手术方法达到翼状胬肉组织切除干净，角膜面平滑及防止复发的目的，一直是眼科同仁较为关注的问题[4-5]。为了获得良好视力和美容效果，而且要降低术后复发率，笔者科室自2010年开始采取复发性翼状胬肉切除联合角膜缘干细胞移植、丝裂霉素应用及羊膜移植，获得了满意疗效，现报道如下。

1 资料和方法

1.1 一般资料：选取2010年1月-2015年12月在笔者医院治疗的复发性翼状胬肉患者46例53眼，其中男22例26眼，女24例27眼；……