卢进兰

[摘要] 目的 研究冠心病心律不齐病例中展开胺碘酮及美托洛尔联治的临床效果，为更好地治疗该病提供参考。方法 从2016年3月—2017年3月期间在该院接受治疗的冠心病心律不齐患者中方便选取213例展开研究，根据治疗方式的不同分组，对照组106例单用胺碘酮进行治疗，观察组107例展开胺碘酮及美托洛尔联合治疗，对比分析两组的临床疗效、治疗前后的心功能情况和不良反应发生率。 结果 治疗后，观察组左室射血分数和心率分别为（48.61±0.32）%、（78.26±4.41）次/min优于对照组，差异有统计学意义（t=4.492，5.799，P<0.05）;观察组临床总有效率为95.33%比对照组高，差异有统计学意义（χ2=4.011，P<0.05），观察组的不良反应发生率为4.67%与对照组比较差异无统计学意义（χ2=1.442，P>0.05）。 结论 应用胺碘桐联合美托洛尔治疗冠心病心律不齐患者不仅有效率高，同时不良反应发生率也不高，值得臨床运用推广。

[关键词] 胺碘酮;美托洛尔;冠心病心律不齐;疗效

[中图分类号] R541          [文献标识码] A          [文章编号] 1674-0742（2018）08（c）-0120-03

Clinical Effect of Amiodarone Combined with Metoprolol in the Treatment of Arrhythmia in Patients with Coronary Heart Disease

LU Jin-lan

Department of Internal Medicine， Dongtai Fourth People's Hospital， Dongtai， Jiangsu Province， 224200 China

[Abstract] Objective To study the clinical effects of amiodarone and metoprolol in the treatment of arrhythmia in patients with coronary heart disease， and provide a reference for better treatment of the disease. Methods A total of 213 patients with coronary heart arrhythmia who were treated in the hospital from March 2016 to March 2017 were convenient selected for study. According to different treatment methods， 106 patients in the control group were treated with amiodarone alone. A total of 107 patients in the observation group were treated with amiodarone and metoprolol. Clinical efficacy， heart function， and incidence of adverse reactions before and after treatment were compared between the two groups. Results After treatment， the left ventricular ejection fraction and heart rate in the observation group were （48.61±0.32）% and（78.26±4.41） times/min were better than those in the control group，the difference was statistically signficant（t=4.492， 5.799， P<0.05）; The effective rate was 95.33% higher than the control group，the difference was statistically signficant（χ2= 4.011， P<0.05）， the incidence of adverse reactions in the observation group was 4.67% compared with the control group， the difference was not significant（χ2=1.442， P>0.05）. Conclusion Amiodarone combined with metoprolol for the treatment of arrhythmia in patients with coronary heart disease is not only highly effective， but also the incidence of adverse reactions is not high， it is worthy of clinical application.

[Key words] Amiodarone; Metoprolol; Coronary heart arrhythmia; Efficacy

冠心病是由于冠状动脉阻塞、器质性狭窄引起缺血所形成的一种心脏疾病，这种疾病发病率高，对患者的日常生活造成了很大的负面影响。此病患者通常会出现心律不齐症状[1]，若任其症状发展，会造成患者心肌耗氧量增加，心肌缺血症状进一步加重，同时还会扩大心肌梗死面积，严重时甚至会导致患者心力衰竭，对患者的生命安全构成威胁。导致冠心病患者心律不齐的主要原因是患者心脏病变引起的心脏异常搏动。胺碘酮以及美托洛尔联治方案为治疗该疾病的主要措施之一。该文从2016年3月—2017年3月期间在该院接受治疗的冠心病心律不齐患者中方便选取213例展开研究，旨在研究胺碘酮联合美托洛尔的治疗效果，现将报道如下。……