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左、右半结肠癌患者临床病理特点及预后差异分析

2018-12-21李院江罗林海

中外医疗 2018年24期
关键词:结肠癌

李院江 罗林海

[摘要] 目的 研究对比左、右半结肠癌患者临床病理特点及预后差异。 方法 回顾性分析2010年5月—2013年6月该院肿瘤科收治的210例结肠癌患者的临床资料,对比左半结肠癌患者(76例)与右半结肠癌患者(134例)的流行病学特征、病理特点及预后生存情况。 结果 左、右半结肠癌患者在男女比例、年龄、首发症状上均差异有统计学意义(χ2=21.960,P<0.05),右半结肠癌患者以高龄者居多,平均年龄为(67.39±2.45)岁,首发症状以腹痛腹泻(80.60%)为主。与左半结肠癌相比,右半结肠癌具有肿瘤直径大,有74.63%的患者肿瘤直径≥5 cm(χ2=13.744),溃疡型患者占79.85%(χ2=10.135),同时具有高分化(5.97%)(χ2=11.740)、淋巴转移(36.57%)(χ2=8.192)、中晚期特点,病理特点比较明显,差异有统计学意义(P<0.05)。左、右半结肠癌在1年生存率(94.12% vs 95.83%)(χ2=0.004)、3年生存率(83.82% vs 81.67%)(χ2=0.065)上差异无统计学意义(P>0.05),右半结肠癌患者5年生存率(59.17%)明显低于左半结肠癌患者(75.00%),差异有统计学意义(χ2=13.657,P<0.05)。 结论 左、右半结腸癌患者临床病理特征差异明显,右半结肠癌患者的生存预后不理想,5年生存率低于左半结肠癌患者。

[关键词] 结肠癌;病理特点;预后

[中图分类号] R735.3          [文献标识码] A          [文章编号] 1674-0742(2018)08(c)-0020-03

Clinical and Pathological Features and Prognosis of Patients with Left and Right Colon Cancer

LI Yuan-jiang, LUO Lin-hai

Department of Gastrointestinal Surgery, Yuxi People's Hospital, Yuxi, Yunnan Province, 653100 China

[Abstract] Objective To compare the clinicopathological features and prognosis of patients with left and right colon cancer. Methods The clinical data of 210 patients with colon cancer admitted to the hospital from May 2010 to June 2013 were retrospectively analyzed. The clinical data, disease characteristics, pathological features, and prognosis of survival of patients with left colon cancer (76 cases) and right colon cancer (134 cases) were compared. Results There were significant differences in the proportion of males and females, age, and initial symptoms between the right and left colon cancer patients (P<0.05). The right-sided colon cancer patients were mostly elderly people with an average age of (67.39±2.45) years old. Diarrhea in abdominal pain (80.60%) (χ2= 21.960) dominated. Compared with left colon cancer, right colon cancer has a large tumor size, with a tumor diameter of ≥5 cm (χ2=13.744) in 74.63% of patients, 79.85% in ulcerative patients (χ2=10.135), and high differentiation (5.97%)(χ2=11.740), lymph node metastasis (36.57%) (χ2=8.192), and late-stage characteristics the pathological features were obvious,the difference was statistically signficant(P<0.05). There was no significant difference in left and right colon cancer at 1-year (94.12% vs 95.83%) (χ2=0.004) and 3-year survival (83.82% vs 81.67%) (χ2=0.065) (P>0.05). The 5-year survival rate of right colon cancer patients (59.17%) was significantly lower than that of left colon cancer patients (75.00%), and the difference was statistically significant (χ2=13.657, P<0.05). Conclusion The clinical and pathological features of patients with left and right colon cancer are significantly different. The survival and prognosis of patients with right colon cancer are not ideal. The 5-year survival rate is lower than that of patients with left colon cancer.

[Key words] Colon cancer; Pathological features; Prognosis

结肠癌是临床常见消化道恶性肿瘤,近年来我国结肠癌发病率与死亡率均呈逐年上升趋势,严重威胁着人们的生命安全,导致生活质量大幅度下降[1]。欧洲肿瘤内科学会提出,依据结肠癌发病部位不同,其在临床症状、病理特点、生存率及治疗方面均存在明显不同,故研究分析左、右半结肠癌的临床病理特点及预后,对于完善结肠癌诊断、治疗及预后理论具有重要价值[2-3]。回顾性分析2010年5月—2013年6月该院肿瘤科收治的210例结肠癌患者的临床资料,现报道如下。

1  资料与方法

1.1  一般资料

回顾性分析共纳入210例结肠癌患者,纳入标准:入院后经临床症状、粪便隐血试验及辅助检查确诊,符合结肠癌临床诊断标准;首次手术治疗,并完整切除肿瘤,术后病理证实为结肠癌;病历及随访资料详细完整。排除标准:依从性差;不同意签署知情同意书。210例结肠癌患者中有男性患者117例,女性患者93例,年龄28~76岁,平均年龄(64.30±9.88)岁,病理类型:左半结肠癌76例,右半结肠癌134例,确诊时间为11 d~1.5年,平均确诊时间(5.49±1.06)个月。……

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