陈瑞丹 李娜 穆亚平

[摘要]目的 探讨一氧化氮（NO）、一氧化氮合酶（NOS）及硫化氢（H2S）水平的变化与婴幼儿轻度轮状病毒肠炎合并良性惊厥的关系。方法 选取2015年9月～2017年4月在沈阳市儿童医院确诊为轻度轮状病毒性肠炎伴良性惊厥患儿50例为观察组，选取同期的单纯轻度轮状病毒肠炎患儿50例为对照组。观察两组患儿的临床特点、常规实验室检查、NO、NOS、H2S变化及观察组的惊厥特点。结果 两组患儿临床特点、常规实验室检查及NO水平比较，差异无统计学意义（P>0.05）。观察组的血清NOS水平显著高于对照组，血清H2S水平显著低于对照组，差异均有统计学意义（P<0.01）。结论 轻度轮状病毒腸炎伴良性惊厥的发生与NO水平无关，与NOS、H2S水平有关，提示可以通过血清中NOS和H2S水平变化预测轻度轮状病毒肠炎患儿良性惊厥的发生。

[关键词]轮状病毒性肠炎；良性惊厥；血清一氧化氮；血清一氧化氮合酶；血清硫化氢

[中图分类号] R725.1 [文献标识码] A [文章编号] 1674-4721（2018）9（a）-0019-04

[Abstract] Objective To explore the relationship between the change of nitric oxide （NO）， nitric oxide synthase （NOS） and hydrogen sulfide （H2S） level in infants with mild Rotavirus enteritis accompanied with benign convulsions. Methods A total of 50 children diagnosed as mild Rotavirus enteritis accompanied with benign convulsion in Shenyang Children′s Hospital from September 2015 to April 2017 were selected as the observation group in Shenyang Children′s Hospital， and 50 children with simple mild Rotavirus enteritis were selected as the control group at the same time. The clinical features， routine laboratory tests， and NO， NOS， H2S changes in children of the two groups and convulsion characteristics of the observation group were observed. Results There was no significant difference in clinical characteristics， routine laboratory examination and NO level between the two groups （P>0.05）. The serum NOS level of the observation group was significantly higher than that of the control group， and the serum H2S level was significantly lower than that of the control group （P<0.01）. Conclusion The occurrence of mild rotavirus enteritis with benign convulsion is independent of NO level， and is related to NOS and H2S level， and it suggests that the incidence of benign convulsions in children with mild Rotavirus enteritis can be predicted by changes in serum NOS and H2S level.

[Key words] Rotavirus enteritis； Benign convulsion； Serum nitric oxide； Serum nitric oxide synthase； Serum hydrogen sulfide

轮状病毒感染是婴幼儿急性肠胃炎的主要原因，占婴幼儿肠道感染的39%左右[1]，5岁以下患儿全球死亡人数约52.7万/年[2]。轮状病毒肠炎常合并神经系统损害，并以良性惊厥多见[3]，癫痫转换率为2%～3%[4]，复发率为4.7%[5]。但目前对于轻度轮状病毒肠炎伴良性惊厥的具体发生机制尚未明确，为进一步明确轻度轮状病毒肠炎伴良性惊厥的发生机制，现选取国内外研究热点血清一氧化氮（NO）、一氧化氮合酶（NOS）及硫化氢（H2S）3个指标进行研究，以明确其是否参与了轻度轮状病毒肠炎伴良性惊厥的发病机制。

1资料与方法

1.1一般资料

选取2015年9月～2017年4月在沈阳市儿童医院确诊为轻度轮状病毒性肠炎伴良性惊厥的患儿50例为观察组，男28例，女22例；月……