程继勇　谭家明

【摘要】 目的：探討无创机械通气联合纳洛酮治疗呼吸衰竭的疗效分析及对患者QOL评分的影响。方法：选取2016年1月-2017年12月本院收治的呼吸衰竭患者80例作为研究对象，根据治疗方案的不同将其均分为两组，对照组40例和研究组40例。对照组采取无创机械通气进行治疗，研究组在对照组基础上联合纳洛酮进行治疗。观察比较两组患者的临床效果，分析对两组患者QOL评分的影响。

结果：研究组总有效率显著高于对照组（P<0.05）；两组患者的GCS与QOL评分均有所升高，但是对照组不显著，研究组评分情况均显著优于对照组（P<0.05）；治疗前两组患者PaO2、PaCO2及SaO2等指标比较差异均无统计学意义（P>0.05），治疗后研究组患者的PaCO2低于对照组，同时PaO2、SaO2均显著高于对照组（P<0.05）；治疗前两组患者酸碱平衡指标比较差异均无统计学意义（P>0.05），治疗后研究组患者的HCO-3与BE均低于对照组（P<0.05），pH无明显变化（P>0.05）。结论：无创机械通气联合纳洛酮治疗呼吸衰竭的临床效果优于单纯无创机械通气，临床效果显著，能改善患者的QOL评分，患者恢复快，有效改善预后，提高患者生活质量，值得在临床上进一步推广应用。

【关键词】 无创机械通气； 纳洛酮； 联合治疗； 呼吸衰竭； 临床效果； QOL评分

Noninvasive Mechanical Ventilation Combined with Naloxone in the Treatment of Respiratory Failure and Its Effect on QOL Score/CHENG Jiyong，TAN Jiaming.//Medical Innovation of China，2018，15（27）：0-049

【Abstract】 Objective：To investigate the efficacy of noninvasive mechanical ventilation combined with Naloxone in the treatment of respiratory failure and its effect on QOL score.Method：A total of 80 cases of respiratory failure treated in our hospital from January 2016 to December 2017 were selected as the research subjects.According to the different treatment plans，they were divided into two groups，40 cases in the control group and 40 cases in the study group.The control group was treated with noninvasive mechanical ventilation，while the study group was treated with Naloxone on the basis of the control group.The clinical effects of two groups were observed and compared，and the influences of two groups on QOL score were analyzed.Result：The total efficiency of the study group was significantly higher than that of the control group（P<0.05）.The scores of GCS and QOL in two groups were increased， the control group were not significant，the scores of the study group were significantly better than those of the control group（P<0.05）.Before the treatment，PaO2，PaCO2，and SaO2 of two groups were compared，there were no significant differences（P>0.05）.The PaCO2 of the study group was lower than that of the control group and the PaO2 and SaO2 were significantly higher than those in the control group（P<0.05）.There was no significant difference in the indexes of acid-base balance between two groups before the treatment（P>0.05）.The HCO-3 and BE in the study group were lower than those in the control group（P<0.05），and pH was not significantly different（P>0.05）.Conclusion：Noninvasive mechanical ventilation combined with Naloxone is better than noninvasive mechanical ventilation in the treatment of respiratory failure.The clinical effect is remarkable.It can improve the patients QOL score，recover the patient quickly，improve the prognosis effectively，and improve the quality of life of the patients.It is worth of further promoting in the clinical application.

【Key words】 Noninvasive mechanical ventilation； Naloxone； Combined treatment； Respiratory failure； Clinical effect； QOL score

First-authors address：Laiwu Central Hospital，Xinwen Mining Group，Laiwu 271103，China

doi：10.3969/j.issn.1674-4985.2018.27.012

临床上将患者肺通气和换气功能发生障碍，呼吸动力和阻力出现不平衡，导致患者出现严重缺氧或者呼吸性酸中毒的现象称为呼吸衰竭[1]。该病是临床呼吸内科中常见的一种疾病，临床表现：患者体内出现二氧化碳含量急剧上升和低氧血症等症状，然后身体上出现一系列的變化。……