刘影林 吴华良 仲伟雁

[摘要]目的 探讨分析乳酸菌阴道胶囊辅助治疗宫颈高危型HPV感染的效果及对微生态环境相关免疫因子的影响。方法 选取2016年5月～2017年8月我院收治的宫颈高危型HPV感染患者8417例，按照随机数字表法分为两组。对照组4205例，采用重组人干扰素α-2b阴道泡腾胶囊治疗，观察组4212例，采用重组人干扰素α-2b阴道泡腾胶囊联合乳酸菌阴道胶囊治疗，对比两组的治疗效果及微生态环境相关免疫因子水平的变化。结果 治疗完成3个月后，观察组的治疗总有效率较对照组高，差异有统计学意义（P<0.05）；观察组微生态环境中白细胞介素-4（IL-4）的水平较对照组要低，干扰素（IFN）-γ、IL-12的水平较对照组高，差异均有统计学意义（P<0.05）。结论 对宫颈高危型HPV感染患者应用乳酸菌阴道胶囊辅助治疗，可有效提高患者的治疗效果，改善微生态环境相关免疫因子水平。

[关键词]重组人干扰素α-2b阴道泡腾胶囊；乳酸菌阴道胶囊；宫颈高危型HPV感染；免疫因子；效果；影响

[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-4721（2018）7（c）-0140-03

[Abstract] Objective To investigate and analyze the effect of Lacidophilin Vaginal Capsules in the treatment of high risk HPV infection of the cervix and the influence on the immune factors related to the microecological environment. Methods A total of 8417 patients with high-risk HPV infection of the cervix were treated in our hospital in May 2016 to August 2017， and they were divided into two groups according to the random number table method. In the control group， 4205 cases were treated with Recombinant human interferon α-2b Vaginal Effervescent Capsules and 4212 cases in the observation group were treated with Recombinant human interferon α-2b Vaginal Effervescent Capsules combined with Lacidophilin Vaginal Capsules， the therapeutic effect of two groups and the changes of immune factors related to microecological environment were statistically compared. Results After 3 months of treatment， the total effective rate of the patients in the observation group were higher than that in the control group， with a statistical difference （P<0.05）. The level of IL-4 in the microenvironment of the observation group were lower than that of the control group， and the levels of IFN-γ and IL-12 were higher than that of the control group， the differences were statistically significant （P<0.05）. Conclusion Lacidophilin Vaginal Capsules adjuvant therapy for cervical high-risk HPV infection can effectively improve the treatment effect and improve the level of immune factors related to microecological environment.

[Key words] Recombinant human interferon α-2b Vaginal Effervescent Capsules； Lacidophilin Vaginal Capsules； High risk HPV infection of the cervix； Immune factors； Effect；Influence

人乳头瘤病毒（HPV）与宫颈病变的发生关系密切，其中高危型HPV感染是引发宫颈癌的主要因素[1]。近幾年，我国HPV感染患者的数量在不断上升并且越来越年轻化，在性活跃期感染率为20%～40%，严重影响患者的身体健康[2]。以往临床对宫颈高危型HPV感染患者主要采用抗病毒药物进行治疗，以消除病毒持续感染，阻断宫颈病变进展，但该类药物在很大程度上破坏阴道内的微生态环境使阴道免疫力降低导致治疗效果不理想[3-4]。随着临床研究的不断深入，乳酸菌阴道胶囊作为一种活菌制剂可有效促进阴道菌群恢复，改善生态环境，进而提高阴道免疫力，使其在临床治疗宫颈高危型HPV感染中被广泛应用[5]。本研究对宫颈高危型HPV感染患者应用不同的治疗方法，分析其治疗效果以及对微生态环境相关免疫因子的影响，现报道如下。……