张军

[摘要] 目的 探讨盐酸羟考酮缓释片在糖尿病合并晚期肿瘤患者癌痛治疗中的效果。方法 选取该院2015年10月—2017年10月收治的糖尿病合并晚期肿瘤重度癌痛患者72例，随机分为2组各36例，观察组给予盐酸羟考酮缓释片，对照组给予硫酸吗啡缓释片，比较效果。 结果 观察组镇痛总有效率为91.7%，不良反应发生率为22.2%，明显优于对照组80.5%、36.1%（P<0.05），观察组镇痛起效时间（58.6±10.4）min，明显优于对照组（97.3±11.7）min（P<0.05）；观察组FBG（6.2±0.4）mmol/L，2 hPBG（8.4±0.5）mmol/L，显著低于对照组（P<0.05）。 结论 盐酸羟考酮缓释片在糖尿病合并晚期肿瘤患者癌痛治疗中，具有显著的镇痛效果，起效快、安全性高，值得应用。

[关键词] 盐酸羟考酮缓释片；糖尿病；肿瘤癌痛

[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2018）03（b）-0082-02

Application of Oxycodone Hydrochloride Controlled-release Tablets in Cancer Pains Treatment of Patients with Diabetes Combined with Advanced Tumor

ZHANG Jun

Department of Pharmacy， Changchun Central Hospital， Changchun， Jilin Province， 130000 China

[Abstract] Objective To study the effect of oxycodone hydrochloride controlled-release tablets in cancer pains treatment of patients with diabetes combined with advanced tumor. Methods 72 cases of cancer pain patients with diabetes combined with advanced tumor admitted and treated in our hospital from October 2015 to October 2017 were selected and randomly divided into two groups with 36 cases in each， the observation group and the control group were respectively treated with oxycodone hydrochloride and morphine sulfate sustained-release tabelets， and the effect was compared between groups. Results The total analgesia effective rate and incidence rate of adverse reactions in the observation group were obviously better than those in the control group （91.7%， 22.2% vs 80.5%， 36.1%）（P<0.05）， and the analgesic onset time in the observation group was obviously better than that in the control group [（58.6±10.4）min vs （97.3±11.7）min]（P<0.05）， and the FBG（6.2±0.4）mmol/L， 2 hPBG（8.4±0.5）mmol/L in the observation group were obviously lower than those in the control group（P<0.05）. Conclusion The analgesic effect of oxycodone hydrochloride controlled-release tablets in cancer pains treatment of patients with diabetes combined with advanced tumor is obvious， with rapid onset and high safety， and it is worth application.

[Key words] Oxycodone hydrochloride； Diabetes； Tumor cancer pains

糖尿病是一种多发性的慢性疾病。近年来，糖尿病已成为我国仅次于恶性肿瘤、心脑血管疾病后危害人类健康和生命的第三大类疾病。经流行病学调查证实[1]，糖尿病和恶性肿瘤之间存在一定的相关性，糖尿病患者罹患癌症的标准化发病率分别为男性1.08%和女性为1.22%。癌痛是肿瘤最常见的伴发症状，也是肿瘤患者最恐惧的症状之一，发生率达60%～75%[2]。当糖尿病合并恶性肿瘤时，不仅可加速肿瘤生长，对患者生存造成威胁，还会使癌痛症状加重，影响患者生活质量。药物镇痛是控制癌痛的主要方法，合理有效的癌痛药物治疗，对改善患者生存和生活质量有重要意义。该研究对该院2015年10月—2017年10月收治的36例糖尿病合并晚期肿瘤重度癌痛患者采用鹽酸羟考酮缓释片治疗，并对其疗效及安全性进行分析，现报道如下。

1 資料与方法

1.1 一般资料

选取该院收治的糖尿病合并晚期肿瘤重度癌痛患者72例为观察对象，随机将患者分为2组各36例，观察组男21例，女15例，年龄35～81岁，平均（60.7±2.1）岁，糖尿病病程4～19年，平均（10.9±1.0）年，食管癌5例，肺癌4例，胃癌7例，胰腺癌2例，结直肠癌11例，乳腺癌5例，卵巢癌2例；……