刘芳 曾惠芬 缪蕙 刘玺 沈明静

[摘要]目的 探讨雷公藤多苷片联合激素和ARB类药物治疗狼疮性肾炎的效果。方法 选取我院2016年1月～2017年12月收治的62例狼疮性肾炎患者作为研究对象，按照随机数字表法分为實验组（31例）和常规组（31例），常规组仅采用激素与ARB类药物治疗，实验组在常规组基础上采用雷公藤多苷片治疗。比较两组治疗效果、治疗后生化指标、不良反应发生情况。结果 实验组的治疗总有效率高于常规组，差异有统计学意义（P<0.05）；实验组C3、C4、ALB明显高于对照组，Cr、尿蛋白、系统性红斑狼疮疾病活动度（SLEDAI）评分明显低于常规组，差异有统计学意义（P<0.05）；实验组不良反应发生率与常规组比较，差异无统计学意义（P>0.05）。结论 雷公藤多苷片联合激素和ARB类药物治疗狼疮性肾炎的效果突出，属于安全、高效的治疗方案，值得推广普及。

[关键词]雷公藤多苷片；激素；ARB类药物；狼疮性肾炎；疗效观察

[中图分类号] R593.242 [文献标识码] A [文章编号] 1674-4721（2018）5（a）-0144-04

[Abstract]Objective To investigate the efficacy of Tripterygium Wilfordii Multi Glucoside combined with hormone and ARB drugs in the treatment of lupus nephritis.Methods From January 2016 to December 2017，a total of 62 patients with lupus nephritis were selected as the study object.They were divided into the experimental group （31 cases） and the routine group （31 cases） by the random number table method.The routine group was treated with hormone and ARB drugs only，and the experimental group was treated with Tripterygium Wilfordii Multi Glucoside Tablets on the basis of routine group.The treatment effect，the biochemical index after treatment and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the experimental group was higher than that in the routine group，the difference was of statistically significant（P<0.05）.The C3，C4 and ALB in experimental group was significantly higher than that in the control group，Cr，urinary protein，SLEDAI score was significantly lower than that in the routine group，the differences were statistically significant（P<0.05）.The adverse reactions rate in the experimental group compared with the routine group，the difference was no statistically significant（P>0.05）.Conclusion Tripterygium Glycosides Tablets combined with hormone and ARB drugs are effective in the treatment of lupus nephritis，it is a safe，effective treatment method，and is worthy of popularization.

[Key words]Tripterygium Wilfordii Tablet；Hormone；ARB drugs；Lupus nephritis；Curative effect observation

系统性红斑狼疮发病机制尚未完全明确，许多研究认为其发病与机体的免疫系统发生改变有关，进而导致全身多脏器损害现象的发生。本病临床上以狼疮性肾炎常见，严重时患者会发生肾衰竭，以糖皮质激素、环磷酰胺冲击治疗为主[1]。近年来，关于狼疮性肾炎的治疗药物不断增多，其中雷公藤多苷片便是代表性药物之一[2]。为了更好地提高狼疮性肾炎的临床治疗效果，本研究以部分无典型特殊性患者为例，探讨雷公藤多苷片、激素、ARB类药物在狼疮性肾炎治疗中的应用效果，现报道如下。

1资料与方法

1.1一般资料

选取我院2016年1月～2017年12月收治的62例狼疮性肾炎患者作为研究对象，按照随机数字法分为实验组和常规组，每组各31例。……