李霞

[摘要] 目的 分析研究硫酸羟氯喹用于类风湿关节炎合并2型糖尿病患者的临床治疗效果。方法 选取该院2015年1月—2017年10月收治的98例类风湿关节炎合并2型糖尿病患者进行分组研究，按照随机数字表法分为对照组（n=49）和观察组（n=49），给予对照组患者甲氨蝶呤联合胰岛素治疗，观察组患者在对照组的基础上加用硫酸羟氯喹治疗，比较两组患者的临床疗效。结果 治疗后，观察组患者临床总有效率为95.92%（47/49）；对照组为79.59%（39/49），两组相比差异有统计学意义（P<0.05）；治疗后，观察组患者空腹血糖（FBG）、餐后2 h血糖（2 hPBG）及糖化血红蛋白（HbAlc）水平均显著低于对照组，观察组患者DAS28 RA活动性评分显著低于对照组，组间差异有统计学意义（P<0.05）。结论 类风湿关节炎合并2型糖尿病患者在临床常规治疗的基础上加用硫酸羟氯喹治疗可以有效的提高临床疗效，有助于患者血糖的控制，其可以改善患者的关节炎症状，具有较高的临床推广价值。

[关键词] 类风湿关节炎；2型糖尿病；硫酸羟氯喹

[中图分类号] R593.22 [文献标识码] A [文章编号] 1672-4062（2018）01（b）-0003-03

Evaluation on Application of Hydroxychloroquine Sulfate in the Treatment of Patients with Rheumatoid Arthritis Combined with Type 2 Diabetes

LI Xia

Western Coastal New District Peoples Hospital， Qingdao， Shandong Province， 266400 China

[Abstract] Objective To analyze and study the clinical effect of hydroxychloroquine sulfate in the treatment of patients with rheumatoid arthritis combined with type 2 diabetes. Methods 98 cases of patients with rheumatoid arthritis combined with type 2 diabetes admitted and treated in our hospital from January 2015 to October 2017 were selected and randomly divided into two groups with 49 cases in each， the control group were treated with methotrexate combined with insulin， while the observation group were treated with hydroxychloroquine sulfate on the basis of the control group， and the clinical curative effect was compared between the two groups. Results After treatment， the total clinical effective rate in the observation group and in the control group was respectively 95.92%（ 47/49） and 79.59%（ 39/49） ， and the difference between the two groups was statistically significant（P<0.05）， after treatment， the FBG， 2 hPBG and HbAlc levels were obviously lower than those in the control group， and the DAS28 RA activity scores in the observation group were obviously lower than those in the control group， and the differences were statistically significant（P<0.05）. Conclusion The hydroxychloroquine sulfate in the treatment of patients with rheumatoid arthritis combined with type 2 diabetes can effectively improve the clinical curative effect， which contributes to the control of blood pressure and improve the arthritis symptoms， and it is of higher clinical promotion and application value.

[Key words] Rheumatoid arthritis； Type 2 diabetes； Hydroxychloroquine sulfate

類风湿关节炎是目前临床上发生率较高的系统性自身免疫性疾病。相关研究表明，类风湿关节炎患者发生心血管疾病的机率远大于正常人，导致这一现象发生的原因可能是由于炎症反应会导致动脉粥样硬化或糖尿病的发生率升高。类风湿关节炎患者的临床特征为炎症反应，进而极易导致糖尿病的发生[1]。同时类风湿关节炎会导致患者产生胰岛素抵抗作用，进而促进糖尿病的发生。目前，临床上类风湿关节炎合并2型糖尿病的人数逐年增长，临床上对于该病的治疗主要以抗疟药物治疗为主，其中常用的包括硫酸羟氯喹和氯喹等[2]。该次研究通过对该院2015年1月—2017年10月收治的98例类风湿关节炎合并2型糖尿病患者进行研究，分析探讨硫酸羟氯喹用于类风湿关节炎合并2型糖尿病患者的临床疗效，现报道如下。

1 资料与方法