余莉

[摘要] 目的 探讨依达拉奉治疗糖尿病合并急性脑梗死的效果。方法 选取该科2017年1月—2018年1月收治的92例糖尿病合并急性脑梗死患者，随机分为两组各46例，对照组给予常规治疗，观察组在对照组的基础上给予依达拉奉，比较疗效。结果 观察组总有效率为91.3%，明显优于对照组78.3%（P<0.05）；观察组空腹血糖（5.8±0.4）mmol/L、NIHSS评分（9.01±1.76）分显著低于对照组，ADL评分（64.73±9.88）分显著高于对照组（P<0.05）。结论 依达拉奉治疗糖尿病合并急性脑梗死效果显著，能明显降低血糖，促进神经功能恢复，提高患者日常生活能力，值得应用。

[关键词] 依达拉奉；糖尿病；急性脑梗死；治疗效果

[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2018）03（a）-0083-02

[Abstract] Objective To study the effect of edaravone in treatment of diabetes combined with acute cerebral infraction. Methods 92 cases of patients with diabetes combined with acute cerebral infraction in our department from January 2017 to January 2018 were selected and randomly divided into two groups with 46 cases in each， the control group used the routine therapy， while the observation group used the edaravone on the basis of the control group， and the curative effect was compared between the two groups. Results The total effective rate in the observation group was obviously better than that in the control group（91.3% vs 78.3%）（P<0.05）， and the fasting blood glucose， NIHSS score in the observation group were respectively （5.8±0.4）mmol/L and（9.01±1.76）points， which were obviously lower than those in the control group， and the ADL score was（64.73±9.88）points， which was obviously higher than that in the control group（P<0.05）. Conclusion The effect of edaravone in treatment of diabetes combined with acute cerebral infraction is obvious， which can obviously reduce the blood glucose， promote the recovery of nerve function and improve the ADL score， and it is worth application.

[Key words] Edaravone； Diabetes； Acute cerebral infraction； Treatment effect

糖尿病是以高血糖為特征的代谢性疾病。糖尿病因长期存在的高血糖，可导致各种组织和血管、神经的慢性损害、功能障碍。糖尿病的血管病变是糖尿病常见的并发症之一，也是导致糖尿病患者死亡的主要原因，尤其合并急性脑梗死时，可进一步加重患者脑部血液供应障碍、神经损伤，引起患者功能衰退或消失，使患者致残、致死率增高。相关研究发现[1]，依达拉奉是一种新型的自由基清除剂，在抑制急性期脑梗死灶周围血流量降低，延长缺血神经细胞生存能力具有良好的效果。为探讨依达拉奉在糖尿病合并急性脑梗死中的效果，该科对2017年1月—2018年1月收治的46例糖尿病合并急性脑梗死患者采用依达拉奉治疗，报道如下。

1 资料与方法

1.1 一般资料

选取该科收治的92例糖尿病合并急性脑梗死患者为观察对象，随机分为两组各46例，观察组男27例，女19例，年龄45～76岁，平均（60.4±1.3）岁，糖尿病病程4～20年，平均（11.3±1.1）年，急性脑梗死发病时间4.2～16.6 h，平均（8.7±0.9）h；对照组男25例，女21例，年龄47～75岁，平均（61.2±1.0）岁，糖尿病病程4～19年，平均（10.4±0.8）年，急性脑梗死发病时间4.7～16.3 h，平均（9.2±0.6）h。……