黄青　洪婷　彭胜男　黄港　徐一博　龙健　王建刚

中圖分类号 R275.9 文献标志码 A 文章编号 1001-0408（2018）02-0229-04

DOI 10.6039/j.issn.1001-0408.2018.02.20

摘 要 目的：观察热敏灸联合枇杷清肺饮加减方治疗寻常性痤疮的临床疗效与安全性。方法：将120例寻常性痤疮患者随机分为对照组与观察组，各60例。对照组患者采用盐酸米诺环素胶囊治疗50 mg/d，bid；观察组患者采用热敏灸（隔日治疗1次）联合枇杷清肺饮加减方（每日1剂，煎至300 mL，早晚分服）治疗。两组均治疗42 d。观察两组患者治疗前、治疗结束后第1天及第90天皮损评分和血清睾酮水平变化情况，评价两组治疗结束后第1天及第90天的临床疗效，并观察两组治疗期间不良反应发生情况。结果：治疗前，两组患者各项指标比较，差异均无统计学意义（P>0.05）。治疗结束后第1天，两组患者各皮损项目评分及血清睾酮水平均较治疗前显著降低，且观察组各皮损项目评分显著低于对照组，差异均有统计学意义（P<0.05），而两组血清睾酮水平比较差异无统计学意义（P>0.05）。治疗结束后第90天，对照组患者各皮损项目评分及血清睾酮水平与治疗前比较，差异均无统计学意义（P>0.05）；观察组患者各皮损项目评分及血清睾酮水平较治疗前显著降低，且显著低于对照组同期，差异均有统计学意义（P<0.05）。观察组患者治疗结束后第1天及第90天的总有效率分别为85.00%、73.33%，显著高于对照组的73.33%、55.00%，差异均统计学意义（P<0.05）。两组患者不良反应发生率比较，差异无统计学意义（P>0.05）。结论：热敏灸联合枇杷清肺饮加减方能够显著降低寻常性痤疮患者的皮损评分及血清睾酮水平，改善皮损症状，安全性较好。

关键词 热敏灸；枇杷清肺饮加减方；寻常性痤疮；疗效；安全性

ABSTRACT OBJECTIVE： To observe the clinical efficacy and safety of of heat-sensitive moxibustion combined with modified Pipa qingfei decoction for acne vulgaris. METHODS： A total of 120 patients with acne vulgaris were randomly divided into control group and observation group， with 60 cases in each group. Control group was given Minocycline hydrochloride capsules 50 mg/d， bid. Observation group was given heat-sensitive moxibustion （every other day） combined with modified Pipa qingfei decoction （one dose every day， decocting to 300 mL， morning and night）. Both groups were treated for 42 d. Skin lesion score and serum testosterone level were observed in 2 groups before treatment， 1st and 90th day after the end of treatment. Clinical efficacies were evaluated in 2 groups on 1st and 90th day after the end of treatment， and the occurrence of ADR was observed in 2 groups during treatment. RESULTS： Before observation，there was no significant difference in these indexes. On 1st day after the end of treatment， the scores of skin lesion items and serum testosterone level in 2 groups were all decreased significantly compared to before treatment， and the scores of skin lesion items in observation group were significantly lower than control group （P<0.05）； there was no significant difference in the serum testosterone level between 2 groups （P>0.05）. On 90th day after the end of treatment， the scores of skin lesion items and serum testosterone level in control group had no statistical significance compared to before treatment （P>0.05）. The scores of skin lesion items and serum testosterone level in observation group were decreased significantly compared before treatment， and were significantly lower than control group at corresponding period （P<0.05）. On 1st and 90th day after the end of treatment， total response rates of observation group were 85.00% and 73.33%， which were significantly higher than 73.33% and 55.00% of control group， with statistical isgnificance （P<0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P>0.05）. CONCLUSIONS： The heat-sensitive moxibustion combined with modified Pipa qingfei decoction can significantly reduce the scores of skin lesion and serum testosterone levels， improves the symptoms of skin lesions， and shows good safety.

KEYWORDS Heat-sensitive moxibustion； Modified Pipa qingfei drink decoction； Acne vulgaris； Therapeutic efficacy； Safety

寻常性痤疮是毛囊和皮脂腺阻塞而引发的慢性炎症性皮肤病，好发于青春期男女，临床可表现为粉刺、丘疹、结节及疤痕等多种皮损形态，属于皮肤科的常见病和多发病，易对患者身心健康产生不良影响[1-2]。西医临……