林素爱 关玲 李慧 王丽华 刘明月 王晓峰 周珊

[摘要]根尖外吸收是继发于正畸牙齿移动的常见临床并发症，轻度的吸收在停止加力后一段时间可自行修复，但中重度的牙根吸收临床上尚缺乏有效对策。为避免这些并发症的出现，国内外学者展开了大量探索。迄今为止，大量体外和动物实验研究对根吸收的修复提供了新的见解和方法。本文主要从药物和物理治疗两个角度总结了可影响牙根吸收修复的相关方法，所提及的方法中对牙根修复的作用原理基本为上调相关矿化因子比值，促进成牙骨质细胞生成，提高牙骨质矿化和沉积。其中，低强度脉冲和低水平激光在治疗过程中还可进一步修复正畸所造成的牙周组织损伤。但这些方法均处于实验阶段，由于牙根吸收的高发性和不可预测性，寻找牙根修复的最佳方法和临床应用，还需进一步研究。

[关键词]正畸；牙根吸收；牙根修复；药物；物理治疗

[中图分类号]R783.5 [文献标志码]A [文章编号]1008-6455（2018）04-0152-03

Effect of Durg Treatment and Physiotherapy on Orthodontical Root Resorption Repair：the Present Status of Research

LIN Su-ai，GUAN Ling，LI Hui，WANG Li-hua，LIU Ming-yue，WANG Xiao-feng，ZHOU Shan

（Harbin Medical University，Harbin 150006，Heilongjiang，China）

Abstract： External apical root resorption is a frequent clinical complication secondary to orthodontic tooth movement. Mild root resorption can be repaired by stopping force.However，there is no effective countermeasure for moderate and severe root resorption in clinic.In order to avoid these complications，domestic and foreign scholars have launched a great deal of exploration.Todata，a substantial number of in vitro and in vivo studies have supplied data that provides new insights into root resorption.The paper summarizes the relevant methods which can affect root resorption from medicine and physics aspests.Some action principles of repair are described in these methods.These action principles include increasing the ratio of related mineralization factors，promoting the producing of cementoblast，improving the mineralization of cementum and raising the deposition of cementoblast.The orthodontic can cause periodontal tissue injuries.Low-level laser therapy and low-intensity pulsed ultrasound，which are mentioned in the summarize，can also repair periodontal tissue injuries. However，these methods are in the experimental stage.Due to the high incidence rate and unpredictability of root resorption in the orthodontic，finding the best method and clinical application of root resurfacing needs further study.

Key words： orthodontics； root resorption； rootrepair； drug； physiotherapy

在正畸治療过程中，超过90%的患者会出现根尖外吸收现象，甚至有15%以上会出现无法修复的严重根尖吸收，从而引起冠根比例失调、牙髓炎等后果[1]。因此，学者们针对如何促进牙根吸收后的修复，从多方面进行了探索，部分方法已初见成效，并在口腔领域有所应用。本文对国内外学者在牙根吸收修复的生物学基础以及相关药物和物理方法的应用对正畸牙根吸收和修复影响的研究现状作一综述。……