戴小敏

[摘要]目的 探討胃炎康胶囊辅助治疗胆汁反流性食管炎的临床效果以及安全性。方法 选取2015年5月～2017年5月于我院就诊的120例胆汁反流性胃炎患者作为研究对象，采用动态随机分组法将其分为观察组和对照组，每组各60例。对照组患者给予铝碳酸镁片，观察组患者在对照组基础上给予胃炎康胶囊辅助治疗。观察两组患者的临床疗效，比较两组患者治疗前后的临床症状评分、胃酸分泌量、胃液胆酸、血浆胃动素（MTL）及血清血管活性肠肽（VIP）含量。结果 观察组患者的治疗总有效率（96.7%）显著高于对照组（85.0%），差异有统计学意义（P<0.05）。治疗前，两组患者的症状评分、胃酸分泌量、胃液胆酸、血清VIP及血浆MTL含量比较，差异无统计学意义（P>0.05）。治疗后，两组患者的症状评分、胃酸分泌量、胃液胆酸、血清VIP含量均显著低于治疗前，差异有统计学意义（P<0.05），且治疗后观察组患者的上述指标均低于对照组，差异有统计学意义（P<0.05）。治疗后，两组患者的血浆MTL高于治疗前，差异有统计学意义（P<0.05），且治疗后观察组患者的血浆MTL显著高于对照组，差异有统计学意义（P<0.05）。两组患者均未出现药物不良反应。结论 胃炎康胶囊辅助治疗胆汁反流性胃炎，能显著提高患者临床治疗有效率，改善各项检查指标，安全性高，值得推广应用。

[关键词]胃炎康胶囊；胆汁反流性胃炎；胃动素；血管活性肠肽

[中图分类号] R975 [文献标识码] A [文章编号] 1674-4721（2018）4（c）-0088-04

The efficacy and safety of Weiyankang Capsule in the treatment of bile reflux gastritis

DAI Xiao-min

Department of Gastroenterology，the People′s Hospital in Wuchuan City，Guangdong Province，Wuchuan 524500，China

[Abstract]Objective To explore the clinical efficacy and safety of Weiyanang Capsule in the treatment of bile reflux esophagitis.Methods A total of 120 patients with bile reflux gastritis treateed in our hospital from May 2015 to May 2017 were selected as subjects and divided into the observation group and the control group by dynamic random grouping method，60 cases in each group.The control group was treated with Hydrotalcite Tablets，while the observation group was given the auxiliary treatment of Weiyankang Capsule on the basis of the control group.The clinical effects were observed between the two groups.And the clinical symptom scores，gastric acid secretion，astric juice cholic acid content，plasma motilin （MTL） and serum vasoactive intestinal peptide （VIP） before and after treatment were compared between the two groups.Results The total effective rate of the observation group （96.7%） was significantly higher than that in the control group of 85.0%，the difference was statistically significant （P<0.05）.Before treatment，there was no significant difference in symptom score，gastric acid secretion，cholic acid in gastric juice，serum VIP and plasma MTL between the two groups （P>0.05）.The symptom score，gastric acid secretion，gastric acid and serum VIP after treament of two groups were significantly lower than before treatment，the differences were statistically significant （P<0.05）.And after treatment，these indexs of the observation group were lower than those of the control group，the differences were statistically significant （P<0.05）.After treatment，the plasma MTL after treament of two groups were significantly higher than before treatment （P<0.05），and the plasma MTL in the observation group was significantly higher than that in the control group，the differences were statistically significant （P<0.05）.There were none adverse drug reactions in the two groups.Conclusion Weiyankang Capsule is an effective adjuvant therapy for bile reflux gastritis.It can significantly improve the clinical effective rate，improve various examination indexes，and is highly safe.It is worthy of popularization and application.

[Key words]Weiyankang Capsule；Bile reflux gastritis；Motilin；Vasoactive intestinal peptide

胆汁反流性胃炎是临床上常见的消化系统疾病，其发病率也呈逐年上升的趋势。胆汁反流性胃炎主要表现为反酸、嗳气、饱胀、隐痛等，其主要是由于胃肠道生理结构异常、幽门生理功能紊乱、消化道手术史等原因导致的胆汁、胆酸等肠道内容物反流至胃内引起的，病理上表现为胃黏膜的慢性炎症[1]。铝碳酸镁可以与胆酸结合，具有保护胃黏膜的作用，减少胆汁反流对胃黏膜的损伤。临床上常使用铝碳酸镁进行治疗，效果虽较好，但易复发。而在中医的范畴内，胆汁反流性胃炎属于呕苦、吞酸、胃脘痛等。胃炎康胶囊属于中药制剂，具有舒肝和胃、缓急镇痛的功效[2]。……