孟锐锐　张连双

【摘 要】目的：探讨复方南星止痛膏联合玻璃酸钠关节腔内注射治疗膝关节软骨损伤的临床效果。方法：选择30例膝关节软骨损伤患者作为本次研究对象，并采用“电脑随机法”将其分为两组，对照组和联合治疗组，每组15例患者。对照组只实施复方南星止痛膏治疗，联合治疗组采用复方南星止痛膏联合玻璃酸钠关节腔内注射治疗，分析两组的疼痛缓解程度。结果：联合治疗组膝关节软骨损伤患者疼痛缓解程度评分低于对照组，差异有统计学意义（P<0.05）。结论：复方南星止痛膏联合玻璃酸钠关节腔内注射治疗膝关节软骨损伤的临床效果优于单独复方南星止痛膏治疗，该研究为膝关节软骨损伤的临床治疗提供了重要的参考依据。

【关键词】玻璃酸钠；复方南星止痛膏；联合治疗；膝关节软骨损伤

linical effect analysis of intra-articular injection of sodium hyaluronate combined with compound Nanxing Zhitong Ointment in the treatment of knee joint cartilage injury

Meng Ruirui1，2，Zhang Lianshuang（Corresponding author）1（1.Basic Medical Sciences College of Binzhou Medical University 2640031 ；2.The Peoples Hospital of Gaoqing County，Shandong Province 2563002）

Abstract：Objective To explore the clinical effect of compound nanxing zhenzhong cream combined with sodium hyaluronate injection in the treatment of cartilage injury of knee joint. METHODS： Thirty patients with knee joint cartilage injury were selected as the study subjects. They were divided into two groups by the “computer randomization method”， the control group and the combined treatment group， with 15 patients in each group. The control group was only treated with Fufang Nanxing Zhitong Ointment. The combination treatment group was treated with Fufang Nanxing Zhitong Ointment and intravitreal injection of Sodium Hyaluronate. The pain relief degree of the two groups was analyzed. RESULTS： The scores of pain relief in patients with knee joint cartilage injury in the observation group were lower than those in the control group （P<0.05）.Conclusion： compound nanxing zhenzhong ointment combined with sodium hyaluronate intra-articular injection is better than compound nanxing zhenzhong ointment alone in the treatment of cartilage injury of the knee. This study provides important reference basis for the clinical treatment of cartilage injury of the knee.

Key words： intra-articular injection of sodium hyaluronate； compound Nanxing Zhitong cream； treatment； knee joint cartilage injury

【中图分类号】R282.5 【文献标识码】A 【文章编号】1005-0019（2018）22-0-01

膝关节软骨损伤是骨科的常见病，近年来发病率呈上升趋势，患者膝关节功能明显受限，若治疗不及时，可严重影响患者的生活质量[1]。由于人体膝关节软骨周围结构特殊，导致其修复缓慢，不仅延长了病程，也增加了患者的心理负担和经济负担，多数患者均进行常规用药治疗，但是由于多种因素影响导致常规治疗方式不佳，近年来复方南星止痛膏在临床广泛应用，其具有一定效果，能改善患者病情，但根据研究资料显示，该药物单一用药效果不佳。玻璃酸钠关节腔内注射为新型治疗方式，但是其与复方南星止痛膏两者联合用药目前在临床上无实验研究报道[2]。因此本研究拟探讨复方南星止痛膏联合玻璃酸钠关节腔内注射对膝关节软骨损伤的疗效，以期为膝关节软骨损伤的临床治疗提供重要的参考依据。……