刁振华+段彩绕

【摘要】 目的 研究小剂量布地奈德福莫特罗干粉吸入剂联合茶碱缓释片治疗中度哮喘患者的临床效果。方法 58例中度哮喘患者， 依据入院时间先后将患者分为观察组和对照组， 各29例。对照组给予小剂量布地奈德福莫特罗干粉吸入剂联合酮替芬分散片治疗， 观察组给予小剂量布地奈德福莫特罗干粉吸入剂联合茶碱缓释片治疗， 比较两组治疗效果及肺功能情况。结果 观察组患者治疗总有效率为96.6%， 显著高于对照组的75.9%， 差异有统计学意义（P<0.05）。治疗后观察组患者第一秒用力呼气容积（FEV1）、FEV1/用力肺活量的比值（FEV1%）明显优于对照组， 差异有统计学意义（P<0.05）。结论 小剂量布地奈德福莫特罗干粉吸入剂联合茶碱缓释片治疗中度哮喘患者效果显著， 能有效控制患者病情并改善其肺功能指标， 值得临床推广。

【关键词】 中度哮喘；布地奈德福莫特罗干粉吸入剂；茶碱缓释片；酮替芬

DOI：10.14163/j.cnki.11-5547/r.2018.02.046

Effect analysis of low-dose budesonide formoterol powder inhalation combined with theophylline sustained-release tablets in the treatment of moderate asthma DIAO Zhen-hua， DUAN Cai-rao. Department of Respiratory Medicine， Shenzhen Longgang District Second Peoples Hospital， Shenzhen 518112， China

【Abstract】 Objective To study the clinical effect of low-dose budesonide formoterol powder inhalation combined with theophylline sustained-release tablets in the treatment of patients with moderate asthma.

Methods A total of 58 patients with moderate asthma were divided by admission order into observation group and control group， with 29 cases in each group. The control group received low-dose budesonide formoterol powder inhalation combined with ketotefen dispersible tablet， and the observation group received low-dose budesonide formoterol powder inhalation combined with theophylline sustained-release tablets. Comparison were made on treatment efficacy and pulmonary function between two groups. Results The observation group had obviously higher total treatment effective rate as 96.6% than 75.9% in the control group， and the difference was statistically significant （P<0.05）. After treatment， the observation group had obviously better forced expiratory volume in

1 second （FEV1）， FEV1 / forced vital capacity （FEV1%） than the control group， and their difference was statistically significant （P<0.05）. Conclusion Low-dose budesonide formoterol powder inhalation and theophylline sustained-release tablets shows remarkable effect in treating moderate asthma， and can effectively control disease condition of patients and improve their pulmonary function indicators. It is worthy of clinical promotion.

【Key words】 Moderate asthma； Budesonide formoterol powder inhalation； Theophylline sustained-release tablets； Ketotifen

支氣管哮喘（简称哮喘）是当前我国临床极为常见的一种慢性呼吸道疾病类型， 以患者气道内炎性病变、平滑肌痉挛为主要病理症状， 对患者身体健康及生活质量均造成严重损害[1]。本次研究将对比小剂量布地奈德福莫特罗干粉吸入剂分别联合酮替芬与茶碱缓释片治疗中度哮喘患者的效果差异， 具体报告如下。

1 资料与方法endprint

1. 1 一般资料 选取2015年8月～2017年8月本院收治的58例中度哮喘患者作为研究对象， 所有患者均符合中华医学会呼吸病学会哮喘学组制定的中度哮喘判定标准[2]。依据入院时间先后将患者分为观察组和对照组， 各29例。观察组患者中男女比例为18∶11， 年龄17～58岁， 平均年龄（30.2±

10.6）岁， 平均病程（3.3±0.6）年。对照组患者中男女比例为17∶12， 年龄17～58岁， 平均年龄（30.5±10.4）岁， 平均病程（3.2±0.5）年。两组患者一般资料比较差异无统计学意义（P>0.05）， 具有可比性。

1. 2 方法

1……