替吉奥胶囊联合调强适形放疗在进展期胃癌中的临床价值
2018-01-23王江涛
王江涛
【摘要】 目的:探究替吉奥胶囊联合调强适形放疗(IMRT)在进展期胃癌的临床价值。方法:选取2017年1月-2018年7月在本院接受进展期胃癌治疗的60例患者为研究对象,根据病区的不同,分为常规组(30例)与干预组(30例),常规组给予单纯调强适形放疗,干预组给予替吉奥胶囊联合调强适形放疗(IMRT),对比两组患者的治疗效果、毒副反应、生活质量以及营养评分。结果:干预组的治疗总有效率为70.00%,明显高于常规组的43.33%,差异有统计学意义(P<0.05)。两组患者均具有较好的耐受性,毒副反应集中于血液毒性的0~Ⅰ期。干预组的生活质量良好率(86.67%)明显高于常规组(56.67%),差异有统计學意义(P<0.05)。治疗后,干预组患者的营养评分为(1.28±0.36)分,低于常规组患者的(2.57±0.23)分,差异有统计学意义(P<0.05)。结论:替吉奥胶囊联合调强适形放疗治疗进展期胃癌,与单纯调强适形放疗比较,提高了患者的营养状况,改善了患者的治疗效果与生活质量,但均具有不同程度的毒副作用,属于患者耐受范围内。
【关键词】 替吉奥胶囊; 调强适形放疗; 进展期胃癌
【Abstract】 Objective:To investigate the clinical value of Tigio Capsule combined with intensity modulated radiation therapy(IMRT) in advanced gastric cancer.Method:60 patients with advanced gastric cancer in our hospital from January 2017 to July 2018 were selected,depending on the area,they were divided into conventional group (30 cases) and intervention group(30 cases).The conventional group was given intensity modulated radiation therapy alone,the intervention group was given Tigio Capsule combined intensity modulated radiation therapy(IMRT).The therapeutic effect,side effects,quality of life and nutritional score in two groups were compared.Result:The total effective rate of intervention group was 70.00%,significantly higher than 43.33% of routine group,the difference was statistically significant(P<0.05).Both groups had good tolerance and the toxicity was concentrated in stage 0-Ⅰ of blood toxicity. The good quality of life rate in the intervention group (86.67%) was significantly higher than that in the routine group (56.67%) (P<0.05).Conclusion:Tigio Capsule combined with intensity modulated radiation therapy in the treatment of advanced gastric cancer,compared with intensity modulated radiation therapy alone,can improve the nutritional status of patients,improve the treatment effect and quality of life of patients,but all have varying degrees of toxicity and side effects,belonging to the tolerance of patients.
【Key words】 Tigio Capsule; Intensity modulated radiation therapy; Advanced gastric cancer
First-authors address:Xiangya Mine Cooperative Hospital,Pingxiang 337000,China
doi:10.3969/j.issn.1674-4985.2018.32.034
胃癌是一种恶性肿瘤,病症起源于胃黏膜上皮,发病率较高,发病人群为50岁以上,临床症状为疼痛、体重减轻、食欲下降等[1]。随着人们生活方式的改变,受到环境、压力等影响,胃癌的发病人群也逐渐年轻化,引起人们的重视。根据癌症细胞的扩散程度,将胃癌分为早期、中期、晚期,临床上对胃癌的治疗常有手术治疗、化疗以及其他治疗[2-3]。胃癌具有早发现早治疗的特点,但当患者胃癌发展为晚期时,则应使用适量的化疗,研究表明,配合药物治疗,有助于缓解患者的发病速度,改善临床症状[4]。本文将对本院60例进展期胃癌患者进行分析,探究替吉奥胶囊联合调强适形放疗(IMRT)在进展期胃癌的临床价值,现报道如下。
1 资料与方法
1.1 一般资料 选取2017年1月-2018年7月来本院接受进展期胃癌治疗的60例患者为研究对象,根据病区的不同,分为常规组(30例)与干预组(30例)。纳入标准:所有患者均经病理活检,诊断为进展期胃癌;……
