罗晓芳

【摘要】 目的：评价胺碘酮联合美托洛尔治疗快速心律失常的效果，并分析联合用药的安全性。方法：本次研究共纳入70例快速心律失常患者，患者均为2015年1月-2017年1月到笔者所在医院就诊，按双色球随机分组法将其分为治疗组（n=35）和对照组（n=35），治疗组患者接受胺碘酮联合美托洛尔治疗，对照组患者仅接受胺碘酮治疗，比较两组患者心率、血压，评价临床疗效，记录不良反应。结果：治疗组总有效率与对照组有效率比较（85.71% vs 68.57%），差异有统计学意义（P<0.05）；治疗后，治疗组的心率和血压水平更接近正常水平，而对照组的血压和心率水平均高于正常水平，两组比较，差异有统计学意义（P<0.05）；治疗组的不良反应率与对照组不良反应率比较（5.71% vs 8.57%），差异无统计学意义（P>0.05）。结论：临床治疗快速心律失常患者采用胺碘酮联合美托洛尔治疗，效果佳，安全性高。

【关键词】 胺碘酮； 美托洛尔； 快速心律失常； 疗效； 安全性

doi：10.14033/j.cnki.cfmr.2017.23.010 文献标识码 B 文章编号 1674-6805（2017）23-0021-02

Analysis of Clinical Effect and Safety of Amiodarone Combined with Metoprolol in the Treatment of Rapid Arrhythmia/LUO Xiao-fang.//Chinese and Foreign Medical Research，2017，15（23）：21-22

【Abstract】 Objective：To evaluate the clinical effects of Amiodarone combined with Metoprolol in the treatment of rapid arrhythmia，and to analyze the safety of combination use of drugs.Method：From January 2015 to January 2017，70 cases with rapid arrhythmia and who admitted in our hospital were included in this study，and the patients were divided into the treatment group（n=35） and the control group（n=35） according to the double chromosphere random grouping method.The treatment group was received Amiodarone combined with Metoprolol，while the control group was received Amiodarone alone.Then，the heart rate and blood pressure were compared between the two groups，the clinical efficacy was evaluated and the adverse reactions were recorded.Result：The total efficiency in the treatment group and the control group（85.71% vs 68.57%） was statistically significant（P<0.05）.After the treatment，the heart rate and blood pressure level in the treatment group were more close to the normal level，while the blood pressure and heart rate in the control group were higher than the normal level，and there were statistically significant difference between the two groups（P<0.05）.The adverse reaction rates in the treatment group compared with the control group（5.71% vs 8.57%），and there was no statistically significant difference（P>0.05）.Conclusion：The clinical treatment of Amiodarone combined with Metoprolol in treatment of patients with rapid arrhythmia are good and the safety are higher.

【Key words】 Amiodarone； Metoprolol； Rapid arrhythmia； Clinical effect； Safety

First-authors address：The Peoples Hospital of Macheng，Macheng 438300，China

快速心律失常屬心血管内科常见病，具有发病急，病情发展快，致死率高的特点。临床主要包括房性心动过速和室性心动过速，对于快速心律失常的治疗，一般以控制患者心室率为主要措施。研究发现，尽早对患者采用药物治疗可大大提高抢救率，由于目前治疗快速心律失常的药物较多，选择安全、有效的药物对患者而言，至关重要[1-2]。胺碘酮是治疗心律失常的有效药物，若与美托洛尔联合应用，可起到协同作用，提高疗效[3-4]。为探讨两种药物联合使用治疗快速心律失常的临床效果及安全性，本研究对70例患者展开研究。endprint

1 资料与方法

1.1 一般资料

将2015年1月-2017年1月笔者所在医院收治的70例快速心律失常患者按双色球随机分为两组。治疗组：35例，其中，房性期前收缩13例，窦性心动过速17例，室性期前收缩5例；……