李玮

[摘要] 目的 了解2014～2016年陕西省汉中市中心医院（以下简称“我院”）抗过敏组胺药的临床应用情况，为临床合理用药提供参考。 方法 对2014～2016年我院抗过敏组胺药总销售金额及排序、抗过敏组胺药用药频度（DDDs）、日均费用（DDC）及排序比（B/A）等进行回顾性统计分析。 结果 3年来我院抗过敏组胺药总销售金额呈逐年降低趋势，尤其是第一代抗过敏组胺药降低尤为明显。各类抗过敏组胺药的销售金额排序变化不大，其中排名前两位药品均为枸地氯雷他定片和地氯雷他定片，西替利嗪滴剂排名逐年靠前，其他药物排序稍有变动。抗过敏组胺药DDDS排名前3位的主要是第三代药物，其中氯雷他定成分药始终排在前列。抗过敏组胺药西替利嗪滴剂的B/A值始终<1，氯苯那敏及异丙嗪的B/A值均>1。处方点评结果中涉及抗过敏组胺药不合理应用现象，主要存在的问题有药物联用不当、剂量不当、给药频次不当等，合计213例。 结论 我院抗过敏组胺药的DDDS排序基本趋向合理，但临床应进一步加强对第二、三代抗组胺的合理应用，以减少不合理用药现象。

[关键词] 抗过敏组胺药；销售金额；用药频度；用药分析

[中图分类号] R969.3 [文献标识码] A [文章编号] 1673-7210（2017）09（b）-0126-04

Clinical application statistics of antihistamine drugs in our hospital from 2014 to 2016

LI Wei

Department of Pharmacy， Hanzhong Central Hospital， Shaanxi Province， Hanzhong 723000， China

[Abstract] Objective To investigate the clinical utilization situation of antihistamine drugs in Hanzhong Central Hospital （"our hospital" for short）， so as to provide references for clinical rational drug use. Methods The total drug sales amounts and sort， DDDs， DDC and sort ratio （B/A） of antihistamine drugs in our hospital from 2014 to 2016 were retrospectively analyzed. Results In the past three years， the trend of total drug sales amount of antihistamine agents decreased year by year， especially the first generation of antiallergic histamines. The sales amount sorting of all kinds of antihistamine drugs had few changes， Desloratadine Citrate Disodium Tablet and Desloratadine Tablet ranked the top two， rankings of Cetirizine raised year after year， other drugs sorting changed slightly. The top three DDDs of antihistamine drugs were the third generation of antiallergic histamines， drugs with Chloropressin composition always ranked the front of the list. The B/A values of Cetirizine Drops were always <1， and the B/A values of Chlorobenzene and Isopropyrazine were all >1. There were irrational use of antihistamine drugs in prescriptions， including improper drug combination， improper dosage， improper frequency for drugs giving， with total of 213 cases. Conclusion The DDDs sort of antihistamine drugs in our hospital is basically reasonable， but the clinical rational application of the second and third generation of antihistamine drugs should be further strengthened， in order to reduce improper use of drugs.

[Key words] Antihistamine drugs； Consumption sum； DDDs； Medication analysis

2005年6月28日，世界變态反应组织（World Allergy Organization，WAO）联合各国变态反应机构共同发起对抗变态反应性疾病的全球倡议，将每年的7月8日定为世界变态反应性疾病日，旨在通过增强全民对变态反应性疾病的认识，共同来预防变态反应的发生。临床上变态反应性疾病涉及的科室及疾病类型较多，如皮肤科、呼吸科、耳鼻喉科、儿科等，并以湿疹、过敏性哮喘、特异性皮炎、过敏性鼻炎等最为常见。……