陈剑峰+张美胡+袁伟明

[摘要]目的 探讨氟西汀联合小剂量利培酮治疗难治性抑郁症的疗效及安全性。方法 选取2012年7月～2016年7月我院收治的70例难治性抑郁症患者作为研究对象。随机将患者分为两组，每组各35例。对照组患者给予氟西汀治疗，观察组加用小剂量的利培酮（0.5～2.0 mg/d）治疗，连续用药12周。比较两组患者的HAMD抑郁评分、CGI-SI疗效评分以及副反应评分。结果 观察组患者在治疗4周末、8周末、12周末的HAMD评分以及CGI-SI评分均低于对照组，差异均有统计学意义（P<0.01）。观察组患者治疗12周末的不良反应评分与对照组比较，差异无统计学意义（P>0.05）。结论 氟西汀与小剂量的利培酮联合治疗能提高治疗效果，促进患者抑郁等症状的缓解，控制病情，且安全性高，值得推广。

[关键词]氟西汀；利培酮；难治性抑郁症；安全性

[中图分类号] R749.4 [文献标识码] A [文章编号] 1674-4721（2017）09（a）-0122-03

The efficacy and safety of Fluoxetine combined with low-dose Risperidone in the treatment of refractory depression

CHEN Jian-feng ZHANG Mei-hu YUAN Wei-ming

Department of the First Internal Medicine，Dongguan Qishi Hospital in Guangdong Province，Dongguan 523500，China

[Abstract]Objective To investigate the efficacy and safety of Fluoxetine combined with low-dose Risperidone in the treatment of refractory depression.Methods From July 2012 to July 2016，70 patients with refractory depression in our hospital were selected as subjects.The patients were randomly divided into two groups，each with 35 cases.The control group was treated with Fluoxetine and the observation group was treated with low-dose Risperidone （0.5-2.0 mg/d），continuous use for 12 weeks.The HAMD depression scores，CGI-SI curative effect evaluation and side effects score of patients in two groups were compared.Results The HAMD score and CGI-SI score of the observation group were lower than those of the control group at the end of 4，8 and 12 weeks after trestment，and the differences were statistically significant （P<0.01）.The score of side effects in the observation group at the end of 12 weeks were compared with the control group，and the difference was not statistically significant （P>0.05）.Conclusion Combination therapy of FLuoxetine and low-dose Risperidone can improve the therapeutic effect，promote the remission of symptoms such as depression，control the diseaseand high safety，it is worth promoting.

[Key words]Fluoxetine；Risperidone；Refractory depression；Safety

難治性抑郁症患者指的是经过两种及以上类型的抗抑郁药物足剂量、足疗程治疗均未见效的患者[1]。氟西汀是常用的抗抑郁药物，但是对于难治性抑郁症的疗效不明显，本研究将其与非典型抗精神病药物利培酮联合起来应用，现报道如下。

1资料与方法

1.1一般资料

选取2012年7月～2016年7月我院收治的70例难治性抑郁症患者作为研究对象。患者均在我院接受足疗程、足剂量的两种及以上类型的抗抑郁药物治疗无效，全部患者均符合难治性抑郁症的相关诊断标准[2]，排除合并严重躯体性疾病、酒精依赖性、药物依赖性的患者及曾联用过其他抗精神病药物的患者。随机将患者分为两组，每组各35例。对照组男20例，女15例；年龄35～72岁，平均年龄（41.8±7.9）岁；……