丁观福

[摘要]目的 探讨辛伐他汀治疗慢性硬膜下血肿的临床效果。方法 收集我院2016年2月～2017年2月收治的慢性硬膜下血肿患者42例为研究对象，按照随机分组的原则分为治疗组和对照组，各21例。治疗组口服辛伐他汀，对照组不给予辛伐他汀，定期随访3个月，利用改良多田公式计算患者各个时期的血肿量，通过Markwalder分级评估患者的神经功能恢复情况，并记录治疗后3个月内患者的血肿复发情况及治疗总有效率。结果 治疗组的总有效率（90.48%）显著高于对照组（61.90%），差异有统计学意义（P<0.05）。结论 辛伐他汀治疗慢性硬膜下血肿的临床效果良好，对患者神经功能的恢复具有促进作用。

[关键词]辛伐他汀；慢性硬膜下血肿；神经功能

[中图分类号] R651.1+5 [文献标识码] A [文章编号] 1674-4721（2017）09（a）-0048-03

Clinical effect of Simvastatin in the treatment of chronic subdural hematoma

DING Guan-fu

The First Affiliated Hospital of Gannan Medical College in Jiangxi Province，Ganzhou 341000，China

[Abstract]Objective To investigate the clinical effect of Simvastatin in the treatment of chronic subdural hematoma.Methods 42 patients with chronic subdural hematoma were collected from Februray 2016 to February 2017.The patients were divided into treatment group and control group according to the principle of randomization grouping and there were 21 cases in each group.The treatment group was treated with Simvastatin and the control group was not given Simvastatin.The patients were followed up for 3 months.The hematopoietic volume of the patients was calculated by modified Tada formula.The recovery of neurological function was evaluated by Markwalder classification.After 3 months treatment，the occurrence of hematoma recurrence and treatment efficiency were recorded.Results The effective rate （90.48%） in the treatment group was significantly higher than those of the control group （61.90%），and the difference was statistically significant （P<0.05）.Conclusion Clinical effect of Simvastatin in the treatment of chronic subdural hematoma is good therapeutic，and has a positive effect on the recovery of neurological function.

[Key words]Simvastatin；Chronic subdural hematoma；Nerve function

慢性硬膜下血腫的临床表现为一个慢性过程，如能明确诊断并给予手术治疗，则可以达到良好的治疗效果。若疗效欠佳或出现患者病死，多因其未及时诊治、病情危重或并发症问题所导致[1]。当前该疾病的治疗以手术方式为主，但是手术具有一定的创伤性，同时术后易复发而且并发癫痫、颅内积气、硬膜下出血、残留血肿等症状，严重影响患者的身心健康及生命安全。有研究提出对于该疾病患者予以辛伐他汀治疗，可促进血肿的吸收，改善患者神经功能。为此，本研究观察我院42例未行手术治疗的患者，予以辛伐他汀治疗，效果理想，现报道如下。

1 资料与方法

1.1一般资料

收集我院2016年8月～2017年2月未行手术治疗的慢性硬膜下血肿患者共42例，按照随机分组的原则分为治疗组和对照组，各21例。治疗组：男12例，女9例，年龄55～90岁，平均（68.8±5.3）岁；……