多西他赛用于合并有糖尿病的乳腺癌患者化疗的安全性探讨
2017-10-20黄山齐
黄山齐
[摘要] 目的 分析多西他赛用于合并有糖尿病的乳腺癌患者化疗的安全性。方法 对该院2014年3月—2017年3月收治的52例乳腺癌合并糖尿病的患者,进行回顾性分析,所有患者在基础降糖治疗,随后进行多西他赛静脉滴注治疗,分析化疗安全性(不给予粒细胞集落刺激因子)。结果 乳腺癌合并有糖尿病的患者基础降糖治疗的总有效率为71.15%,行多西他赛静脉滴注治疗后总有效率为96.15%。II期患者和IV期患者的不良反应发生率分别为30.76%和7.69%。结论 多西他赛用于合并有糖尿病的乳腺癌患者化疗有着较高的安全性,值得进一步研究发展。
[关键词] 多西他赛;糖尿病;乳腺癌;化疗
[中图分类号] R737.9 [文献标识码] A [文章编号] 1672-4062(2017)06(a)-0079-02
[Abstract] Objective This paper tries to analyze the safety of chemotherapy for patients with diabetes mellitus and diabetes mellitus. Methods 52 cases of diabetes with breast cancer patients in this hospital from March 2014 to March 2017 were selected and analyzed retrospectively; all patients had basic hypoglycemic treatment as well as the docetaxel intravenous drip treatment, and then the chemotherapy safety would be analyzed (not given granulocyte colony stimulating factor). Results The total effective rate of hypoglycemic treatment for patients with diabetes mellitus combined with breast cancer was 71.15% and the total effective rate after taking the docetaxel intravenous drip treatment was 96.15%. The incidence of adverse reactions in patients with stage II and IV was 30.76% and 7.69% respectively. Conclusion Docetaxel has high safety in chemotherapy for patients with diabetes mellitus combined with breast cancer, and it deserves further study.
[Key words] Docetaxel; Diabetes; Breast cancer; Chemotherapy
多西他赛作为一种化疗药物,对治疗乳腺癌有着较好的疗效。但是其可以引起较为严重的过敏现象以及体液潴留,所以使用前需要用地塞米松来处理[1]。但是地塞米松对于合并糖尿病的乳腺癌患者来说,其会对血糖有所影响,因此是否能够使用多西他赛进行相应化疗是医护人员要考虑的问题2014年3月—2017年3月。该次研究通过对合并有糖尿病的乳腺癌患者使用多西他赛进行治疗以及安全性的观察,得出的结论共医生参考,现报道如下。
1 资料与方法
1.1 一般资料
对该院收治的52例合并有糖尿病的乳腺癌患者进行观察,所有患者符合合并糖尿病的乳腺癌疾病诊断标准。该组患者最大年龄为74岁,最小年龄为49岁,平均年龄为(60.32±3.14)岁。II期患者26例,IV期患者26例,分析该组患者在治疗前后的临床数据,发现差异无统计学意义,具有可比性。……
