司琳娜

摘要：目的 探究肝硬化患者肠道菌群失调与Child-Pugh分级的关系，并研究其治疗方法与效果。方法 选取2015年5月～2016年5月我院收治的50例肝硬化患者，选取同期健康体检者50例，对肠道菌群进行研究。肝硬化组在常规治疗上采用益生菌治疗，观察其治疗效果。结果 肝硬化组患者中肠球菌、肠杆菌明显多于健康体检组；另外肝硬化组患者中的双歧杆菌明显少于健康体检组。Child-PughA级、B级与C级患者中双歧杆菌依次减少，且C级下降最明显。另外，肠杆菌与肠球菌在A级、B级、C级中依次增多，C级增加最明显。与治疗前比较，治疗后双歧杆菌与肠球菌明显增加，肠杆菌明显下降。结论 肝硬化患者的肝功能严重程度与肠道菌群失调程度有着密切联系，采用益生菌治疗可以明显改善患者肠道菌群失调症状，促进患者治疗效果的提高，具有较高的临床应用价值。

关键词：肝硬化；腸道菌群； Child-Pugh分级

中图分类号：R575.2 文献标识码：A 文章编号：1006-1959（2017）20-0060-02

Abstract：Objective To investigate the relationship between intestinal flora imbalance and Child-Pugh classification in patients with cirrhosis，and to study the treatment methods and effects.Methods 50 cases of liver cirrhosis were selected from May 2015～May 2016 in our hospital，50 cases of healthy subjects were selected and studied on the intestinal flora.The cirrhosis group with probiotics treatment on the basis of conventional treatment， the therapeutic effect was observed.Results The patients with liver cirrhosis were enterococcus，enterobacteria were significantly higher than the healthy group；also in patients with liver cirrhosis the bifidobacteria was significantly less than the healthy group.Child-PughA level，B level and C level in patients with bacillus bifidus decreased，and C level decreased most obviously.In addition，enterobacter and enterococcus in Grade A，grade B， grade C were increased，C level increased obviously.Compared with before treatment，bifidobacterium and enterococcus were increased after treatment， enterobacteriaceae decreased significantly.Conclusion The severity of liver function in patients with liver cirrhosis is closely related to the degree of intestinal flora imbalance.The use of probiotics can improve the symptoms of intestinal flora and improve the therapeutic effect of patients with high clinical value.

Key words：Liver cirrhosis；Intestinal flora；Child-Pugh classification

身体肝脏器官中的各种生物机制均与肠道有着紧密联系，肠道菌群具有多种功能，能够维持微生物对潜在病原进行屏蔽，同时会对肠壁运动与灌注产生一定的影响，能够刺激肠道免疫系统，减少细菌出现位移现象，并可以适当的产生维生素[1]。在肝硬化患者中常见的特征为小肠细菌过度生长，并且肝硬化患者通常会出现不同程度的肠道菌群失调情况，需要对其加以重视，并采取有效的治疗措施，提高患者的预后[2]。本研究通过对我院收治的50例肝硬化患者进行研究分析，现报告如下。……