段锦龙　姚魁武　冯潇潇　曹珏　于宙

[摘要] 胸痹在现代医学主要属于冠心病范畴，中医药治疗胸痹疗效显著。该研究采用网络药理学的方法对中医药治疗胸痹方剂核心中药配伍的潜在作用机制进行了系统的研究。首先，筛选中国期刊全文数据库（CNKI）中运用中医方剂治疗胸痹的临床研究文献。其次，运用中医传承辅助平台软件（V2.5）建立数据库，分析中医药治疗胸痹的用药规律及核心中药配伍。最后，通过BATMANTCM在线分析工具对核心中药配伍进行KEGG通路分析，揭示核心中药配伍治疗胸痹的潜在作用信号通路。结果表明，临床治疗胸痹的核心中药配伍其作用的潜在信号通路为钙离子和cGMPPKG信号通路。该研究为中医药治疗胸痹用药规律和作用机制研究提供了一种新的研究策略。

[关键词] 胸痹； 中医药； 网络药理学； 中医传承辅助平台； BATMANTCM

Mechanism analysis of traditional Chinese medicine in clinical

treatment of thoracic obstruction based on network pharmacology

DUAN Jinlong1， YAO Kuiwu1*， FENG Xiaoxiao1， CAO Jue1，2， YU Zhou1

（1. Guang′anmen Hospital， China Academy of Chinese Medical Sciences， Beijing 100053， China；

2. Beijing University of Chinese Medicine， Beijing 100029， China）

[Abstract] Thoracic obstruction is mainly attributed to the scope of coronary heart disease in modern medicine， and traditional Chinese medicine（TCM） shows a significant effect in the treatment of thoracic obstruction. In this research， a network pharmacology method was carried out to systemically study the underlying mechanism of the core herbal compatibility in TCM on the thoracic obstruction. First， we collected the literature about TCM prescriptions for treating thoracic obstruction from CNKI. Then， a prescription database was establish by TCM inheritance support platform system（V2.5） to determine the medication rules and core herbal compatibility in TCM. Finally， to obtain the potential signaling pathways， KEGG pathway analysis was performed by BATMANTCM online analysis tool. Results showed that the potential signal pathway of core herbal compatibility in TCM for the clinical treatment of thoracic obstruction was calcium ion and cGMPPKG signaling pathway. This study provided a new research strategy for the study of the medication rules and mechanism of traditional Chinese medicine in the treatment of thoracic obstruction.

[Key words] thoracic obstruction； traditional Chinese medicine（TCM）； network pharmacology； TCM Inheritance Support Platform System； BATMANTCM

胸痹是以胸部憋悶或发作性心胸疼痛，重则胸痛彻背，短气，喘息不得卧等为主要表现的一种疾病。在现代医学主要属于冠心病范畴，因其高的发病率和死亡率，严重危害百姓的健康[1]。研究表明，中医药可以改善血管内皮功能[2]，减少血小板聚集，抑制炎症反应[3]，清除氧自由基[4]，进而改善冠心病患者的临床症状。现阶段对胸痹的相关文献研究主要集中在中医病因研究、经验总结及古代医案分析等几个方面，缺少对于用药规律及作用机制的深入研究。本文收集整理了近10年中医药治疗胸痹的临床研究文献，并对胸痹用药规律及潜在作用信号通路进行了分析，为今后胸痹的临床和基础研究提供参考。……