李民凤++++++罗秋林++++++唐前梅

[摘要] 目的 探讨辛伐他汀联合依折麦布治疗冠心病的效果及对TC、LDL-C、ApoB的影响。 方法 选取2015年10月～2016年10月重庆市人民医院三院院区收治的冠心病患者96例，按随机数字表法分为对照组和观察组，每组各48例。对照组采用辛伐他汀治疗，观察组采用辛伐他汀联合依折麦布治疗，均治疗3个月。比较两组血脂达标率及用药不良反应发生情况，并测定两组治疗前后血清胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）及载脂蛋白（ApoB）水平变化。 结果 观察组治疗后TC、LDL-C、ApoB均低于對照组，差异有统计学意义（P < 0.05）；观察组血脂达标率高于对照组，差异有统计学意义（P < 0.05）；观察组不良反应发生率略高于对照组，但差异无统计学意义（P > 0.05）。 结论 辛伐他汀联合依折麦布治疗冠心病有良好的调脂效果，血脂达标率较高，且用药安全。

[关键词] 冠心病；辛伐他汀；依折麦布；调脂治疗

[中图分类号] R541 [文献标识码] A [文章编号] 1673-7210（2017）08（b）-0048-04

[Abstract] Objective To analyse the clinical effects of Simvastatin combined with Ezetimibe in the treatment of patients with coronary heart disease and its influence for TC， LDL-C， ApoB. Methods From October 2015 to October 2016， 96 patients with coronary heart disease in the Third Branch of Chongqing People's Hospital were selected and divided into control group （48 cases） and observation group （48 cases）. The control group was treated by Simvastatin， while the observation group was treated by Simvastatin combined with Ezetimibe. Three months after treatment， the compliance rate and adverse drug reactions of two groups were compared， and the changes of serum cholesterol （TC）， low density lipoprotein cholesterol （LDL-C） and apolipoprotein （ApoB） levels were measured before and after treatment between two groups. Results The levels of TC， LDL-C and ApoB in the observation group were lower than those in the control group （P < 0.05）. The rate of blood lipid in the observation group was higher than that in the control group， with statistically significant difference （P < 0.05）. The incidence of adverse reactions in the observation group was higher than that in the control group， but the difference was not statistically significant （P > 0.05）. Conclusion Simvastatin combined with Ezetimibe for coronary heart disease has a good effect in the regulate lipid， which has a high achievement rate of serum lipid and safety of medication.

[Key words] Coronary heart disease； Simvastatin； Ezetimibe； Lipid lowering therapy

冠心病是临床常见的心血管疾病，多由冠状动脉硬化引起心肌缺血、缺氧所致，多发生于老年人。随着近年人们生活方式的改变，以及社会老龄人口的不断增加，冠心病的发生率呈上升趋势。冠心病的发生，多伴有胆固醇（total cholesterol，TC）、低密度脂蛋白（low density lipoproteincholesterol，LDL-C）及载脂蛋白（porcine apolipoprotein，ApoB）水平降低，尤其LDL-C是诱发冠心病发生的主要危险因素之一[1]。他汀类药物如辛伐他汀是临床治疗冠心病的一线药物，可显著降低LDL-C水平。而依折麦布是近年来临床广泛用于治疗冠心病的降脂药物，其是一种胆固醇吸收抑制剂，可降低TC水平。两种药物联合使用，在相互协同作用下，在调脂方面效果更为显著[2]。故本文对2015年10月-2016年10月重庆市人民医院三……