急性ST段抬高心肌梗死患者经皮冠脉介入治疗近期预后的危险因素分析
2017-09-22王音
王音
[摘要] 目的 分析急性ST段型抬高心肌梗死(ASTEMI)患者經皮冠脉介入(PIC)治疗近期预后的危险因素,为临床评估预后提供参考。 方法 选择2012年1月~2017年1月于宝鸡市中医医院行PIC治疗的130例ASTEMI患者的临床资料,并进行回顾性分析。根据患者的近期预后情况将其分为两组:合并主要不良心血管事件(MACE)组(48例)及无MACE组(82例)。统计两组患者的性别、年龄、体重指数、Killip分级、并发症、左心室射血分数(LVEF)、超敏C反应蛋白(hs-CRP)、脑钠肽前体(NT-proBNP)、梗死部位、病变支数、Hb及肾功能等数据资料,采用多因素Logistic回归模型分析ASTEMI患者近期预后的影响因素。 结果 单因素分析分析结果显示,两组患者性别、年龄、体重指数、Killip分级、梗死部位及高脂血症、高血压病、脑卒中及LVEF<40%患者占比比较,差异无统计学意义(P > 0.05);两组糖尿病、病变支数≥1、hs-CRP > 4 mg/L、NT-proBNP > 3600 pmol/L、HbA1C≥ 6.5%、血肌酐> 133 mmol/L、肾小球滤过率(GFR)< 90 mL/(min·1.73m2)占比及Hb水平分布比较,差异有统计学意义(P < 0.05)。多因素Logistic回归分析结果显示,hs-CRP、HbA1c、GFR、Hb、NT-proBNP是ASTEMI患者经皮冠脉介入治疗近期发生MACE的危险因素(P < 0.05)。结论 hs-CRP、HbA1c、GFR、Hb、NT-proBNP是ASTEMI患者经皮冠脉介入治疗近期不良预后的危险因素,临床上应给予针对性的治疗,改善患者的预后。
[关键词] ST段型抬高心肌梗死;经皮冠脉介入;不良心血管事件;近期预后
[中图分类号] R541 [文献标识码] A [文章编号] 1673-7210(2017)08(b)-0044-04
[Abstract] Objective To analyze the risk factor of recent prognosis of patients with ST-elevation myocardial infarction after percutaneous coronary intervention (PIC). Methods The clinical data of 130 patients with ST-elevation myocardial infarction treated after PCI in Traditional Chinese Medicine Hospital of Baoji City from January 2012 to January 2017 were retrospectively analyzed. They were divided into two groups according to the recent prognosis: MACE group (48 cases) and non-MACE group (82 cases). Sex, age, body mass index, Killip classification, complications, LVEF, hs-CRP, NT-proBNP, kidney function and other clinical data of patients were eliminated; the influencing factors of the recent prognosis of patients with ST-elevation myocardial infarction after PIC were analyzed by multi-factor Logistic regression model analysis. Results Single factor analysis showed that, there was no statistically significant difference in the sex, age, body mass index, Killip classification, area of infarction, and the proportion of patients with hyperlipemia, hypertension, stroke and LVEF < 40% between the two groups (P > 0.05); the proportion of patients with diabetes mellitus, number of stenosed coronary vessel ≥ 1, hs-CRP > 4 mg/L, NT-pro BNP > 3600 pmol/L, HbA1c ≥ 6.5%, SCr > 133 mmol/L, GFR < 90 mL/(min·1.73 m2),and level of Hb of patients between the two groups had statistically significant difference (P < 0.05). Logistic regression analysis showed that, hs-CRP, HbA1c, GFR, Hb, NT-proBNP were the influence factors of MACE in patients with st-elevation myocardial infarction (P < 0.05). Conclusion hs-CRP, HbA1c, GFR, Hb, NT-proBNP are risk factors of major adverse cardiovascular events of patients with ST-elevation myocardial infarction after PCI; the clinical should carry corresponding treatment, to improve the prognosis of patients.endprint
[Key words] ST-segment elevation myocardial infarction; Percutaneous coronary intervention; Adverse cardiovascular events; Recent prognosis
急性心肌梗死(acute myocardial infarction,AMI)是冠状动脉急性、持续性缺血缺氧所致的急性心肌坏死,临床表现多为剧烈、持久的胸骨后疼痛,休息及硝酸酯类药物不能完全缓解,实验室检查可见心电图及血清心肌酶活性增高,急性ST段型抬高心肌梗死(ST segment elevation myocardial infarction,ASTEMI)是极为常见的一种心肌梗死,严重者可出现休克或心力衰竭而危及生命。随着我国人口老年化进程的加剧、生活习惯及饮食结构的改变,越来越多的老年人成为了急性心肌梗死的高危人群,老年心肌梗死患者占比逐年升高。目前,临床上最常见的治疗方式是经皮冠脉介入(percutaneous coronary intervention,PCI)和溶栓治疗,而临床疗效并不十分显著,尤其由于老年患者多合并多种疾病,病情复杂,近期及远期疗效均可能受到影响[1-3]。研究显示,A……
