李穗华+罗金现

[摘要]目的 研究适形调强放疗+口服卡培他滨对Ⅱ、Ⅲ期直肠癌术后患者的治疗效果。方法 选取2013年2月～2015年3月我院诊治的86例直肠癌Ⅱ、Ⅲ期患者，随机分成研究组与对照组，各43例。全部患者均常规实施手术治疗，研究组在术后对患者实施适形调强放疗与卡培他滨联合治疗，对照组术后单纯应用适形调强放疗治疗，评价分析患者的治疗效果。结果 研究组的总有效率（83.72%）明显高于对照组（62.79%），差异有统计学意义（P<0.01）；研究组的术后2年无病生存率、总生存率明显高于对照组，局部复发率明显低于对照组，差异有统计学意义（P<0.05）；研究组的不良反应发生率（44.19%）也明显低于对照组（65.12%），差异有统计学意义（P<0.01）。结论 Ⅱ、Ⅲ期直肠癌患者在手术治疗后给予适形调强放疗与卡培他滨口服联合治疗，具有显著的临床效果。

[关键词]直肠癌；Ⅱ、Ⅲ期；适形调强放疗；卡培他滨

[中图分类号] R735.37 [文献标识码] A [文章编号] 1674-4721（2017）08（c）-0039-03

[Abstract]Objective To study and analyze the treatment effects of conformal intensity-modulated radiation therapy and oral Capecitabine for postoperative care of patients with stage Ⅱ and Ⅲ rectal cancer.Methods 86 cases of patients with stage Ⅱ and Ⅲ of rectal cancer and who received the treatment in our hospital from February 2013 to March 2015 were selected，and the patients were randomly divided into study group and control group，with 43 cases in each group.All the selected patients were implemented the routine surgery treatment，and the study group were implemented conformal intensity-modulated radiotherapy combined with Capecitabine，while the control group were only treated with conformal intensity-modulated radiation therapy.Then，the clinical effect of two groups was evaluated and analyzed.Results The treatment efficiency in the study group was 83.72%，which was significantly higher than that in the control group of 62.79%，with statistical significance （P<0.01）；the disease-free survival rate， overall survival rate and local recurrence rate after the operation for 2 years in the study group were significantly better than those in the control group， with statistical significance （P<0.05）.And the incidence of adverse reactions in the study group was 44.19%，which was significantly lower than that in the control group of 65.12%， with statistical significance （P<0.01）.Conclusion The treatment effects of conformal intensity-modulated radiotherapy combined with Capecitabine oral administration for patients with stage Ⅱ and Ⅲ rectal cancer，which it has significant clinical effect.

[Key words]Rectal cancer；Stage Ⅱ and Ⅲ；Conformal intensity-modulated radiotherapy；Capecitabine

直腸癌是临床常见的一种消化系统恶性肿瘤，通常好发于40岁以上的中老年人群[1]。近年来，由于人们生活方式、饮食结构一直在改变等因素的影响，使直肠癌的发病率表现为逐渐上升的趋势，严重危害了人们的生命安全[2]。手术治疗是直肠癌患者的重要治疗方法，大部分早期患者经手术切除治疗后均可获取满意的疗效。但因直肠癌患者的病变位置比较特殊，解剖结构比较复杂，手术预后情况常常会受到多种因素的影响，尤其是对于中晚期患者，在术后极易出现复发及远处转移等情况，而导致患者死亡[3]。因此，对中晚期患者实施有效的辅助治疗，将其预后情况改善，提高其术后生存期，具有重要的意义。放疗是临床常用的直肠癌术后辅助治疗措施，为提高患者治疗预后效果，本研究分析了适形调强放疗+口服卡培他滨对Ⅱ、Ⅲ期直肠癌术后患者的治疗效果，报道如下。……