金伟

[摘要]目的 評价氨氯地平联合阿托伐他汀钙在高血压伴高血脂中的应用效果。方法 选取我院2015年5月～2016年5月收治的120例中老年高血压伴高血脂患者，随机分为两组，每组60例。对照组：单一使用氨氯地平；观察组：在对照组基础上，联用阿托伐他汀钙。比较两组的治疗效果和治疗期间的不良反应发生率。结果 治疗后，两组患者的收缩压（SBP）、舒张压（DBP）均显著降低（P<0.05），且观察组降低幅度大于对照组（P<0.05）；治疗后，两组患者的总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白-胆固醇（LDL-C）、高密度脂蛋白-胆固醇（HDL-C）均有明显改善（P<0.05），且观察组的改善情况优于对照组（P<0.05）；观察组的总有效率93.33%，对照组为80.00%，观察组疗效明显优于对照组（P<0.05）。观察组的不良反应发生率为0.03%，对照组为0.05%，两组差异无统计学意义（P>0.05）。结论 氨氯地平联合阿托伐他汀钙药效明显优于单独使用氨氯地平，联合药物能有效达到调血脂、降血压的治疗效果，安全性高，具有较高的临床推广价值。

[关键词]氨氯地平；阿托伐他汀钙；高血压；高血脂

[中图分类号] R544.1 [文献标识码] A [文章编号] 1674-4721（2017）06（a）-0051-03

[Abstract]Objective To evaluate the application effect of Amlodipine combined with Atorvastatin Calcium in the treatment of patients with hypertension and hyperlipidemia.Methods 120 elderly patients with hypertension and dyslipidemia treated in our hospital from May 2015 to May 2016 were selected and were randomly divided into two groups with 60 cases in each group.The patients in the control group were only treated with Amlodipine while the patients in the observation group were treated with Atorvastatin Calcium based on the treatment of the control group.Treatment effect and the incidence rate of adverse reaction occurred during treatment between two groups were compared.Results After treatment，systolic blood pressure （SBP） and diastolic pressure （DBP） were significantly decreased in the two groups （P<0.05），and those in the observation group were significantly lower than those of the control group （P<0.05）.After treatment，the total cholesterol （TC），triglyceride （TG），low density lipoprotein （LDL-C） and high density lipoprotein （HDL-C） of the patients in two groups were significantly improved （P<0.05），and those in the observation group were improved better than those in the control group （P<0.05）.The total effective rate of the observation group was 93.33%，while that of the control group was 80.00% and the curative effect in the observation group was better than that of the control group （P<0.05）.The incidence of adverse reactions was 0.03% in the observation group while that was 0.05% in the control group，but the difference was not statistically significant （P>0.05）.Conclusion The pesticide effectof Amlodipine combined with Atorvastatin Calcium is obviously better than the single use of Amlodipine.Combined drugs can effectively achieve the effect of lipid-lowering and lowering blood pressure.This treatment has high safety and a high clinical value.

[Key words]Amlodipine；Atorvastatin calcium；Hypertension；Hyperlipidemia

长期高血压伴高血脂是诱发动脉粥样硬化性血管疾病（脑血管疾病的一种）的重要病因，且高血压伴高血脂已是全球医学重疾之一。近年来，我国脑血管疾病患者死亡或瘫痪的数量位居榜首[1]，尤其是生活水平的改善，导致我国血脂异常人员逐年递增，对中老年人群身心健康造成严重影响，其中高血压与高血脂患者达到3亿人次。高血压伴高血脂的症状同步加剧了动脉粥样硬化的发生[2]，该病发病急、病程长，是反复发作的慢性疾病，长期服用单一药品氨氯地平，由于药物成分的关系导致药效一般，且疗效稳定性不强[2]。近年来，我院在高血压伴高血脂的治疗中联用阿托伐他汀钙，旨在调脂降压，该种经济有效的临床治疗方案取得了较满意的效果，现报道如下。……