龙春梅+陈定贵+郑中伟

[摘要] 目的 探究药物性肝损伤的临床特点及相关药物分析。方法 对2010年1月—2016年1月该院收治的药物性肝损伤患者资料进行研究，通过回顾性分析方式对92例药物性肝损伤患者的一般资料、用药情况、表现、相关性药物等特点进行总结。结果 在初发症状中，68例患者表现为乏力，60例患者出现纳差，58例患者出现尿黄，只有15例患者表现为肝功能异常。中药导致药物性肝损伤的几率最高，约占43.5%，抗结核类药物其次，占10.9%，抗肿瘤类药物、精神类药物、抗菌类药物、解热镇痛类药物分别占6.5%。结论 中年女性是药物性肝损伤患者的易发群体，中药则是导致肝损伤的主要药物类型，其中，肝细胞型损伤为主，患者预后情况良好。

[关键词] 药物性肝损伤；用药情况；临床特点；预后

[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）05（c）-0121-03

[Abstract] Objective To study the analysis of clinical features and related drugs of 92 cases of patients with Drug-induced liver injury. Methods The patients with drug-induced liver injury admitted and treated in our hospital from January 2010 to January 2016 were selected and the general data， medication， manifestations and related drugs of the 92 cases were summarized by the retrospectively analysis method. Results 68 cases were weak， 60 cases were with poor appetite， 58 cases were with yellow urine and only 15 cases were with liver function abnormality， and the probability of drug-induced liver injury caused by the TCM is the highest， accounting for 43.5%， and the anti-tuberculosis drugs were the second， accounting for 10.9%， and the antineoplastic drugs， psychotropic drugs， antibacterial drugs， antipyretic analgesics respectively accounted for 6.5%. Conclusion The middle-aged females are the susceptible population with drug-induced liver injury， and the TCM is the main drug type of liver injury， and the hepatocellular injury is the main and the prognosis of patients is good.

[Key words] Drug-induced liver injury； Medication； Clinical features； Prognosis

临床上，药物性肝损伤发病率逐年上升，这也引起了临床医师的广泛关注。相关研究资料指出，约有千余种药物能导致患者药物性肝损伤，甚至也会出现药物致肝衰竭的病例[1]。当前，药物性肝损伤的发病机理尚未全面清楚，在疾病临床特点、诊断治疗等方面仍存在一定问题。为探究药物性肝损伤的临床特点及相关药物分析，该文方便选择2010年1月—2016年1月该院收治的药物性肝损伤患者92例资料进行研究，现报道如下。

1 资料与方法

1.1 一般资料

方便选择该院收治的药物性肝损伤患者资料進行研究，纳入标准：①患者均与药物性肝损伤临床诊断标准相吻合[2]。……