刘宗武

DOI：10.16662/j.cnki.1674-0742.2017.11.137

[摘要] 目的 探讨左卡尼汀治疗冠心病心力衰竭的效果。方法 方便选取该院2013年12月—2016年12月收治的冠心病心衰患者202例，随机分为两组各101例，对照组给予常规治疗，观察组在对照组的基础上给予左卡尼汀治疗，比较两组疗效。结果 观察组总有效率为95.1%，显著优于对照组79.2%（P<0.05）；治疗后观察组LVEF（61.89±7.12）%、CO（5.0±0.51）L/min、SV（62.1±9.13）mL等指标显著优于对照组（P<0.05）。结论 左卡尼汀可有效改善心肌细胞能量代谢，增强心功能，效果显著，值得应用。

[关键词] 左卡尼汀；冠心病心力衰竭；疗效

[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-0742（2017）04（b）-0137-03

Study on Curative Effect of Levocarnitine in Treatment of Heart Failure Caused by Coronary Artery Disease

LIU Zong-wu

Department of Cardiology， Jilin Provincial Peoples Hospital， Changchun， Jilin Province， 130000 China

[Abstract] Objective To study the effect of levocarnitine in treatment of heart failure caused by coronary artery disease. Methods 202 cases of patients with heart failure caused by coronary artery disease admitted and treated in our department from December 2013 to December 2016 were selected and randomly divided into two groups with 101 cases in each， the control group adopted the routine treatment， while the observation group were treated with levocarnitine， and the curative effect was compared between the two groups. Results The total effective rate in the observation group was obviously better than that in the control group（95.1% vs 79.2%）（P<0.05）， after treatment， the LVEF， CO and SV in the observation group were respectively （61.89±7.12）%， （5.0±0.51）L/min and （62.1±9.13）mL， which were obviously better than those in the control group（P<0.05）. Conclusion Levocarnitine can effectively improve the myocardial energy metabolism and enhance the cardiac function， and the effect is obvious， which is worth application.

[Key words] Levocarnitine； Heart failure caused by coronary artery disease ； Curative effect

冠心病是临床常见的慢性心血管疾病。近年来，我国冠心病人群逐年呈增多趨势。根据国家心血管病中心发布的《中国心血管病报告2013》显示[1]，全国心血管病患者约有2.9亿人，冠心病发病率占15.6%～31.7%。冠心病患者由于动脉腔内狭窄，血流受阻，心脏长期缺血、缺氧，心肌收缩力减弱，微循环灌注不足，最终导致心力衰竭的发生，严重危害了患者的生命。研究也表明[2]，70%以上的心力衰竭是由冠心病引起的。治疗过程中恢复心肌能量代谢，减轻和预防心肌损伤是提高患者心功能的关键。左卡尼汀又名左旋肉毒碱[3]，可通过参与脂肪酸代谢和糖氧化，减少缺血期长链脂酰肉碱的堆积对心肌的毒性，促进心肌能量代谢的恢复。该文对该院2013年12月—2016年12月收治的101例冠心病心衰患者采用左卡尼汀治疗，探讨左卡尼汀在治疗冠心病心衰中的效果，现报道如下。

1 资料与方法

1.1 一般资料

方便选取该院收治的冠心……