刘元山

DOI：10.16662/j.cnki.1674-0742.2017.11.135

[摘要] 目的 通过对急性胰腺炎患者进行奥曲肽不同给药方法的治疗，比较和分析其不同，并得到更加优良的治疗方法。方法 方便选取该院2012年4月—2017年1月收治的14～86岁急性胰腺炎患者共62例，其中男性患者37例，女性患者25例；将其随机分成A、B两组，A组31例（男性19例，女性12例）采用微量输液泵静滴奥曲肽，B组31例（男性18例，女性13例）采用静脉滴注奥曲肽，对比两组治疗效果差异。结果 A组在发热恢复时间、腹痛恢复时间以及血淀粉酶所恢复到正常数值的时间明显低于B组，且A组住院时间明显低于B组，差异有统计学意义（P<0.05）；A组总有效率93.55%，B组总有效率为77.42%，相比之下，A组疗效更好（P<0.05）。 结论 采用微量泵输注奥曲肽的方法治疗急性胰腺炎效果更好，能有效维持血液浓度稳定，更快缓解病人症状，值得临床上推广。

[关键词] 奥曲肽；给药方法；急性胰腺炎；疗效

[中图分类号] R576 [文献标识码] A [文章编号] 1674-0742（2017）04（b）-0135-03

Evaluation of Clinical Curative Effect of Different Administration Methods of Octreotide in Treatment of Acute Pancreatitis

LIU Yuan-shan

Digestive System Department， Pizhou Peoples Hospital， Pizhou， Jiangsu Province， 221300 China

[Abstract] Objective To compare and analyze the clinical curative effect of different administration methods of octreotide in treatment of acute pancreatitis and obtain a better treatment method. Methods 62 cases of patients with acute pancreatitis aged between 14 and 86 from April 2012 to January 2017 were convenient selected including 37 males and 25 females， and randomly divided into two groups with 31 cases in each， the group A （19 males and 12 females） adopted the intravenous infusion of octreotide by the themicroinfusion pump， while the group B （18 males and 13 females） adopted the intravenous infusion of octreotide， and the difference in the treatment effect was compared between the two groups. Results The fever recovery time， bellyache recovery time and time to return to normal of hemodlastase in the group A were obviously lower than those in the group B， and the length of stay in the group A was obviously lower than that in the group B， and the difference was statistically significant（P<0.05）， and the total effective rate in the group A was better than that in the group B，（93.55% vs 77.42%）（P<0.05）. Conclusion The curative effect of intravenous infusion of octreotide by the themicroinfusion pump in the treatment of acute pancreatitis is better， which can effectively maintain the steady blood concentration and rapidly relieve the symptoms of patients， and it is worth clinical promotion.

[Key words] Octreotide； Administration method； Acute pancreatitis； Curative effect

奧曲肽为一种人工合成的八肽环状化合物，拥有与自然内源性生长抑素近似的功能，但作用比较突出而且持续时间长，半衰期是天然抑素的30倍左右。奥曲肽可以减少胃部活动，抑制胆囊排空，抑制胰酶泌素的分泌，还可以减少胰腺的分泌，所以本品可以更好地保护胰腺实质细胞；奥曲肽也有降低内脏血流量、调节门脉压力、缓解肠道分泌和增强肠道对水和Na+的吸收[1]。临床上出现急性腹痛，并伴有恶心、呕吐、发热，或者患者出现血胰酶增高时，很可能属于急性胰腺炎症状[2]，是消化科常见的疾病，它是由于多种病因所引发的胰腺组织自身出现消化、出血等症状，或者更严重的出现水肿甚至坏死的炎症反应。……