任雪军　罗文秀　黎晓燕　谢洋

【摘要】 目的：探究采用持续脑功能监测对早期诊断新生儿低血糖脑损伤的意义。方法：选取本院收治的低血糖症患儿60例，记录患儿出生后1 d振幅整合脑电图显示结果，并在出生后3 d时行头颅MRI及CT检测，对比分析检测结果。在患儿2、6月龄时，评估心理及神经发育情况。结果：振幅整合脑电图检查后脑功能正常、轻度及重度脑损伤发生率分别为26.67%、33.33%、40.00%与头颅MRI检测结果（26.67%、35.00%、38.33%）相比，差异均无统计学意义（P>0.05）。脑功能正常患儿2、6月龄时，心理神经功能正常患儿分别占87.50%、81.25%，与脑功能异常患儿（22.73%、18.18%）相比，差异均有统计学意义（P<0.05）。结论：新生儿低血糖脑损伤时采用持续脑功能早期监测的意义显著，能准确检测患儿脑功能，诊断价值较好，与患儿神经系统发育存在重要联系。

【关键词】 新生儿； 低血糖症； 脑损伤； 持续脑功能早期监测； 预后

Application Value of Continuous Brain Function Monitoring in Early Diagnosis of Neonatal Hypoglycemic Brain Injury/REN Xue-jun，LUO Wen-xiu，LI Xiao-yan，et al.//Medical Innovation of China，2017，14（15）：094-097

【Abstract】 Objective：To explore the significance of continuous brain function monitoring in early diagnosis of neonatal hypoglycemic brain injury.Method：A total of 60 cases with neonatal hypoglycemic brain injury in our hospital were selected.Results of amplitude integrated electroencephalo-graph（EEG） in 1 day after birth and brain MRI and CT in 3 days after birth were compared and analysed.When they were 2 and 6 months old，psychological and neural development were assessed.Result： The incidence of normal brain function，mild and severe brain injury through the amplitude integrated EEG were respectively 26.67%，33.33% and 40%，and those through brain MRI and CT were 26.67%，35% and 38.33%，the differences were no statistically significant（P>0.05）.When they were 2 and 6 months old，proportion of normal psychological and neurological function of children with normal brain function were respectively 87.50% and 81.25%，significantly higher than 22.73% and 18.18% of children with abnormal brain function（P<0.05）.Conclusion：The significance of the early continuous monitoring of cerebral injury in neonatal hypoglycemia is significant，it can accurately detect the brain function of children，the diagnostic value is good，and there is an important link between the nervous system development and the childrens nervous system.

【Key words】 Newborn； Hypoglycemia； Brain injury； Early continuous monitoring of brain function； Prognosis

First-authors address：Dongguan Maternal and Child Care Service Centre，Dongguan 523120，China

doi：10.3969/j.issn.1674-4985.2017.15.027

新生兒低血糖是一种常见的临床代谢问题，是导致脑损伤的重要原因[1]。轻者对婴幼儿的神经系统造成破坏，重者可导致严重的脑损伤，甚至猝死。许多疾病都会导致低血糖的发生，低血糖可使脑细胞失去基本能量来源，脑代谢和生理活动无法进行，如不及时纠正会造成永久性脑损伤[2]。因此早期发现低血糖及寻找有效的早期评价脑损伤的诊断方法至关重要。振幅整合脑电图（aEEG）应用于新生儿重症监护病房（NICU）已逐步获得认可[3-4]。为进一步研究新生儿低血糖脑损伤时采用持续脑功能早期监测的意义与预后效果，本院特选取30例新生患儿资料进行研究。现报道如下。

1 资料与方法

1.1 一般资料 随机选取2014年6月-2016年3月本院收治的低血糖患儿60例，其中男32例，女28例，平均胎龄（38.25±1.14）周；平均体重（2.86±0.32）kg。该……