岳阳平

【摘要】 目的：探讨血清肿瘤相关物质（TAM）检测在甲状腺癌中的诊断价值。方法：选取2012年1月-2014年6月的69例甲状腺癌患者作为甲状腺癌组，113例甲状腺良性结节患者作为甲状腺良性结节组，194例健康体检者作为健康体检组，三组均进行血清TAM检测，观察三组的检测结果。结果：甲状腺癌组的血清TAM明显高于甲状腺良性结节组和健康体检组，差异均有统计学意义（P<0.001）；且甲状腺良性结节组的血清TAM高于健康体检组，差异有统计学意义（P<0.05）。甲状腺癌组的阳性率明显高于甲状腺良性结节组和健康体检组，差异均有统计学意义（P<0.001）；甲状腺良性结节组和健康体检组的阳性率比较，差异无统计学意义（P>0.05）。结论：血清肿瘤相关物质检测在评估甲状腺良恶性结节方面有一定的诊断价值，是一种有效的鉴别诊断方法。

【关键词】 血清肿瘤相关物质； 甲状腺癌； 甲状腺良恶性结节； 鉴别诊断

The Diagnostic Value of Detection of Serum Tumor Associated Material in Thyroid Carcinoma/YUE Yang-ping.//Medical Innovation of China，2017，14（15）：114-117

【Abstract】 Objective：To explore the diagnostic value of detection of serum tumor associated substances in thyroid carcinoma.Method：69 patients with thyroid carcinoma from January 2012 to June 2014 were selected as thyroid carcinoma group，113 patients with benign thyroid nodules were selected as benign thyroid nodules group，194 healthy subjects were selected as health examination group，serum tumor associated substances （TAM） were detected in three groups，and the results of the three groups were observed.Result：The serum TAM of thyroid carcinoma group was significantly higher than those of benign thyroid nodules group and healthy examination group，the differences were statistically significant（P<0.001）；and the serum TAM of thyroid benign nodules group was higher than that in healthy group，the difference was statistically significant（P<0.05）.The positive rate of thyroid carcinoma group was significantly higher than those of benign thyroid nodule group and healthy examination group，the differences were statistically significant（P<0.001）；there was no significant difference in the positive rate between benign thyroid nodule group and healthy examination group （P>0.05）.Conclusion：The detection of serum tumor associated substances in the diagnosis of benign and malignant thyroid nodules has a certain diagnostic value，it is an effective method for differential diagnosis.

【Key words】 Serum tumor associated material； Thyroid cancer； Benign and malignant thyroid nodules； Differential diagnosis

First-authors address：Huizhou Third Peoples Hospital，Guangzhou Medical University，Huizhou 516002，China

doi：10.3969/j.issn.1674-4985.2017.15.033

甲状腺结节是內分泌系统的常见疾病之一，在一般人群中很常见，通过触诊的检出率为3%～7%，高分辨率超声的检出率高达20%～76%，其中5%～15%的甲状腺结节为甲状腺癌[1]。近年来，甲状腺结节以及甲状腺癌的患病率逐年增高[2]，甲状腺结节的评估要点就是鉴别良恶性，如何有效的评估结节良恶性，从而减少不必要的穿刺和手术、避免医疗风险、降低医疗费用，在甲状腺结节的诊治中显得尤为重要。目前临床采用多种方法来评估甲状腺结节的良恶性，血清肿瘤相关物质（Tumor Associated Material，TAM）在人体血清中进行表达的一类糖胺类物质及羟脯氨酸类物质，其包括糖脂、糖蛋白、羟脯氨酸以及细胞表面的聚糖结构等，肿瘤发生时，其在体内的含量增高[3-4]。本研究就血清肿瘤相关物质（TAM）检测在甲状腺癌中的诊断价值做一探讨，现报告如下。

1 资料与方法

1.1 一般资料 选取2012年1月-2014年6月的初诊患者，甲状腺癌患者69例作为甲状腺癌组，均经穿刺或手术后病理确诊为甲状腺癌，其中男28例，女41例，年龄19～75岁，平均（49.2±13.3）岁；……