徐绍敏　刘玉学　董泽清

[摘要] 目的 探讨丹参川芎嗪注射液对急性肺挫伤患者白细胞介素-8（IL-8）、血清肿瘤坏死因子-α（TNF-α）的影响。方法 将2014年6月～2016年6月在我科接受治疗的60例急性肺挫伤患者按随机数字表法分为对照组29例和治疗组31例，其中对照组予西医常规治疗，治疗组在对照组治疗的基础上辅以丹参川芎嗪注射液静脉滴注，两组疗程均为10 d。比较两组患者平均住院时间、肺部感染率、急性呼吸窘迫综合征（ARDS）发生率等继发性肺损伤指标，并观察两组患者血清IL-8、TNF-α水平变化情况。 结果 两组临床基线一致，治疗组患者第10天的血清IL-8、TNF-α水平较对照组明显降低，且治疗组的平均住院时间较对照组患者明显减少。 结论 丹参川芎嗪注射液能显著改善急性肺挫伤患者IL-8、TNF-α水平，促进肺功能恢复，疗效显著，值得临床推广。

[关键词] 急性肺挫伤；丹参川芎嗪注射液；白细胞介素-8；肿瘤坏死因子-α

[中图分类号] R26 [文献标识码] B [文章编号] 1673-9701（2016）33-0092-03

[Abstract] Objective To investigate the effects of Danshen Ligustrazine for injection on interleukin-8（IL-8） and serum tumor necrosis factor-α（TNF-α） in the patients with acute lung contusion. Methods 60 patients with acute pulmonary contusion who were given the treatment in our department from June 2014 to June 2016 were divided into the control group（n=29） and the treatment group（n=31） according to the method of random number table. The control group was treated with routine western medicine， and the treatment group was given intravenous drip of Danshen Ligustrazine for injection on the basis of the treamtent in the control group. The course of treatment was 10 days in both groups. The indices of secondary lung injury such as average hospital stay， pulmonary infection rate， and incidence rate of acute respiratory distress syndrome（ARDS） were compared and analyzed between the two groups， and the changes of serum IL-8 and TNF-α levels in the two groups were observed. Results The clinical baseline was consistent in both groups. The levels of serum IL-8 and TNF-α in the treatment group were significantly lower than those in the control group at the tenth day， and the average hospital stay in the treatment group was significantly shorter than that in the control group. Conclusion Danshen Ligustrazine for injection can significantly improve the level of IL-8 and TNF-α in patients with acute lung contusion， and promote the recovery of pulmonary function， which has a significant curative effect and is worthy of clinical promotion.

[Key words] Acute lung contusion； Danshen ligustrazine for injection； Interleukin-8； Tumor necrosis factor-α

肺挫傷是临床最为常见的胸部钝性伤，如未及时有效处理可发展为急性呼吸窘迫综合征（ARDS），甚至多器官功能衰竭（MOF），是导致胸部外伤死亡的原因之一[1，2]。鉴于此，肺挫伤的发病机制及其治疗方法已逐渐成为该领域的研究热点。本研究对我院2014年6月～2016年6月60例急性肺挫伤患者采用常规西医治疗和在此基础上加用丹参川芎嗪注射液两种方式治疗，分析应用丹参川芎嗪注射液对肺挫伤患者治疗效果的影响。现报道如下。

1 资料与方法

1.1 一般资料

选择2014年6月～2016年6月在我科接受治疗的60例急性肺挫伤或以肺挫伤为主的患者，入选标准：①年龄18～80岁；……