张卫军　王瑞霞

[摘要] 目的 探讨生化检验项目在肝硬化中的作用。 方法 通过对2014年2月～2016年10月在我院治疗的90例肝硬化患者临床资料进行回顾性分析，肝硬化患者为实验组，选取同期在我院健康体检的人员为对照组，观察比较两组生化结果差异。 结果 实验组患者总蛋白、总胆红素、胆碱酯酶、透明质酸、Ⅲ型前胶原、层黏连蛋白、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、γ-谷氨酰转肽酶水平同对照组比较，差异具有统计学意义（P<0.05），肝硬化患者不同分级白蛋白、胆酰酯酶水平比较差异有统计学意义（P<0.05）。 结论 针对肝硬化患者采用生化检验项目、纤维化指标为肝硬化诊断提供重要依据，采取积极治疗措施，缓解患者病情发展，改善预后，临床值得推广应用。

[关键词] 肝硬化；生化检验；纤维化；价值

[中图分类号] R575.2 [文献标识码] B [文章编号] 1673-9701（2017）11-0091-03

Analysis of the value and test results of biochemical test items in liver cirrhosis

ZHANG Weijun1 WANG Ruixia2

1.Medical Laboratories， Lanzhou University Second Hospital， Lanzhou 730030， China； 2.Department of Interventional Radiography， Lanzhou University Second Hospital， Lanzhou 730030， China

[Abstract] Objective To explore the role of biochemical test items in cirrhosis. Methods The clinical data of 90 patients with liver cirrhosis who were treated in our hospital from February 2014 to October 2016 were retrospectively analyzed. The patients with liver cirrhosis were assigned to the experimental group， and the subjects receiving physical exam in our hospital were selected as the control group at the same period. The differences of biochemical results between the two groups were observed. Results The total protein，total bilirubin，cholinesterase， hyaluronic acid，type III procollagen，laminin protein level，alanine aminotransferase， aspartate aminotransferase，γ-Glutamyl transpeptidase in the experimental group were significantly different from those in the control group， and the differences were statistically significant（P<0.05）. There were significant differences in different classifications of albumin and cholinesterase levels in the patients with liver cirrhosis（P<0.05）. Conclusion The biochemical test items and fibrosis indicators are used to provide important evidences for the diagnosis of liver cirrhosis in the patients with liver cirrhosis. The positive treatment measures are taken to alleviate the development of the disease and improve the prognosis， which is worthy of clinical application and popularization.

[Key words] Liver cirrhosis； Biochemical tests； Fibrosis； Value

肝硬化為临床较为常见疾病，发病率较高，患者早期症状不明显，在临床诊断过程中易被忽视，导致病情加重，肝脏功能损害影响其他系统，使患者出现感染、癌变、上消化出血等严重并发症，直接威胁患者生命安全[1-2]。因此，对早期肝硬化寻找有效指标，具有重要意义，临床多通过尿常规、免疫学指标、血常规、内镜等进行检查，随着生化技术的不断发展，生化检验在肝硬化诊断中发挥重要作用，生化指标可协助医生了解肝细胞代谢指标及受损程度。本文通过对我院收治的90例肝硬化患者临床资料进行分析，讨论生化检验项目在肝硬化诊断中的意义，现报道如下。

1 资料与方法

1.1 一般资料

选取于我院治疗的90例肝硬化患者，其中男59例，女31例，年龄39～76岁，平均（54.04±5.41）岁，病程2个月～9年，平均（2.72±0.96）年；选取同期于我院健康检查的90例患者为对照组，其中男56例，女34例，年龄40～77岁，平均（56.36±5.27）岁。纳入标准[3]：患者经临床诊断均符合肝硬化诊断标准，患者均进行超声、CT等检查，患者均自愿参与并签署知情同意书。……