张英

[摘要] 目的 分析沙利度胺联合卡培他滨节拍化疗治疗转移性乳腺癌的临床疗效及安全性。方法 研究对象方便选取该院2012年6月—2015年5月收治的76例转移性乳腺癌患者，采用电脑随机的方式分为研究组与参比组各38例。研究组患者接受沙利度胺联合卡培他滨节拍化疗治疗；参比组患者行常规化疗。对两组患者的疗效、不良反应情况进行观察对比。 结果 研究组患者的治疗有效率为63.16%（24/38），对比参比组患者的68.42%（26/38），差异无统计学意义（P>0.05）；研究组患者骨髓抑制反應发生率为39.47%、手足综合征10.53%、消化道不良反应18.42%，参比组患者为71.05%、26.32%和42.86%，差异有统计学意义（P<0.05）。结论 沙利度胺联合卡培他滨节拍化疗治疗转移性乳腺癌的疗效与常规化疗接近，但是不良反应发生率明显更低。

[关键词] 利度胺；卡培他滨；节拍化疗；转移性乳腺癌；安全性

[中图分类号] R737.9 [文献标识码] A [文章编号] 1674-0742（2017）01（c）-0142-03

Analysis of Clinical Curative Effect and Safety of Thalidomide and Capecitabine in the Metronomic Chemotherapy of Metastatic Breast Cancer

ZHANG Ying

Department of Medical Oncology， Inner Mongolia Autonomous Region People's Hospital，Hohhot，Inner Monglia， 010010 China

[Abstract] Objective To analyze the clinical curative effect and safety of thalidomide and capecitabine in the chemotherapy of metastatic breast cancer. Methods 76 cases of patients with metastatic breast cancer admitted and treated in our hospital from June 2012 to May 2015 were convenient selected and randomly divided into two groups with 38 cases in each， the research group were treated with thalidomide and capecitabine， while the control group were treated with routine method， and the curative effect and adverse reactions of the two groups were observed and compared. Results The difference in the treatment effective rate between the research group and the control group had no statistical significance[63.16%（24/38） vs 68.42%（26/38）]，（P>0.05）； the differences in the incidence rate of bone marrow suppression reaction， hand-foot syndrome and gastrointestinal side effect between the research group and the control group had statistical significance（39.47%， 10.53%， 18.42% vs 71.05%， 26.32%， 42.86%）（P<0.05）. Conclusion The curative effect of thalidomide and capecitabine in the chemotherapy of metastatic breast cancer is similar to that of the routine chemotherapy， but the incidence rate of adverse reactions is lower.

[Key words] Thalidomide； Capecitabine； Metronomic chemotherapy； Metastatic breast cancer； Safety

乳腺癌在女性中具有较高的发病率，对患者生命健康及生活质量的影响非常大。加上晚期转移的可能性高，治疗的难度也相对较大[1-2]。针对转移性乳腺癌，常规的治疗方式有化疗、内分泌治疗，而内分泌治疗失败的情况下只能够接受化疗。众所周知，常规的最大耐受剂量化疗的效果虽然较好，但是产生的毒副作用也非常大，还可能导致耐药性。因此，探讨的更为安全、有效的治疗方案非常关键。该文方便选取该院2012年6月—2015年5月收治的76例转移性乳腺癌患者进行分析，探讨沙利度胺联合卡培他滨节拍化疗与常规化疗的效果与安全性，现报道如下。

1 资料与方法

1.1 一般资料

研究对象方便选取该院收治的76例转移性乳腺癌患者，所有患者均通过病理学诊断确诊[3]，患者的预计生存期在3个月以上。采……