禤昭银+辛振杰+廖羽明+陈宗武+钟志冰+罗杏

[摘要]目的 探討多用磨浆机在粉碎天灸药物白芥子中的应用及临床观察。方法 选取2014年6月本院的80例无皮肤过敏的自愿受试人员，按照随机数字表法分为对照组A和治疗组A，各40例。对照组A在相应穴位敷贴传统方法制备的天灸稠膏，治疗组A在相同穴位敷贴多用磨浆机法制备的天灸稠膏，观察两组的皮肤刺激性、起效时间和发热程度。选取2014～2016年7、8月本院门诊收治的160例虚寒型哮喘患者，按照随机数字表法分为对照组B和治疗组B，各80例。对照组B在相应穴位敷贴传统方法制备的天灸稠膏，治疗组B在相同穴位敷贴多用磨浆机法制备的天灸稠膏，比较两组的治疗效果。结果 治疗组A在1、24、48、72 h的反应平均分值高于对照组A，差异有统计学意义（P<0.05）。治疗组A人体皮肤的起效时间短于对照组A，发热程度强于对照组A，差异有统计学意义（P<0.05）。治疗组B的总有效率为91.25%，高于对照组B的77.50%，差异有统计学意义（P<0.05）。结论 多用磨浆机粉碎白芥子制备的天灸稠膏对人体皮肤的刺激较强，对虚寒型哮喘的疗效较高，值得临床推广应用。

[关键词]白芥子；传统粉碎；多用磨浆机粉碎；天灸稠膏；虚寒型哮喘

[中图分类号] R931.4 [文献标识码] A [文章编号] 1674-4721（2017）01（c）-0112-03

[Abstract]Objective To explore the application and clinical observation of the multi-purpose refiner in smashing White Mustard Seed of moxibustion medicine.Methods 80 tested volunteers who had no skin allergy in June 2014 in our hospital were selected and divided into the control group A and the treatment group A according to the random number table method.The control group A was applied the moxibustion thick paste made with the traditional method in the relevant acupoint，the treatment group A was applied the moxibustion thick paste made with the multi-purpose refiner in the same acupoint.The skin irritation，onset time and fever degree of the two groups were observed.In addition，160 patients with deficiency and cold type asthma in our hodpital in July and August from 2014 to 2016 were selected and divided into the control group B and the treatment group B according to the random number table method.The control group B was applied the moxibustion thick paste made with the traditional method in the relevant acupoint，the treatment group B was applied the moxibustion thick paste made with the multi-purpose refiner in the same acupoint.The treatment effect was compared between the two groups.Results The reaction average scores at 1，24，48，and 72 h in the treatment group A was higher than that in the control group A，with significant difference （P<0.05）.The onset time of human skin in the treatment group A was shorter than that in the control group A，and the fever degree in the treatment group A was stronger than that of the control group A，with significant difference （P<0.05）.The total effective rate in the treatment group B was 91.25%，which was higher than that in the control group B（77.50%），with significant difference （P<0.05）.Conclusion The moxibustion thick paste made with the multi-purpose refiner has a strong stimulation in human skin and has high curative effect for deficiency and cold type asthma in clinic，it is worthy of clinical promotion and application.

[Key words]White Mustard Seed；Traditional smashing；Multipurpose refiner smashing；Moxibustion thick plaster；Deficiency and cold type asthma

白芥子是十字花科一年生或多年生草本植物白芥（Sinapisalba L.）的种子[1]，有研究显示白芥子外用对皮肤有促渗透作用，可使皮肤发热、发红、甚至起泡，是冬病夏治穴位贴敷的主要药物之一，每年夏季的三伏天在相应穴位上敷贴以白芥子为主药的稠膏对治疗慢性支气管炎、支气管哮喘、过敏性鼻炎等疾病均有较好效果，可是按传统方法制成的天灸稠膏，贴敷于穴位时具有粗粒感，影响疗效。本研究采用多用磨浆机按湿法粉碎法来研磨生白芥子制备天灸稠膏，这是根据多用磨浆机的原理设计，可适合于粉碎含挥发性成分的药材[2-5]，能够迅速粉碎白芥子，获得细粉，与余下药物混合制成稠膏，用其进行皮肤刺激性对比试验，同时再进行临床治疗虚寒型哮喘的效果对比，现报道如下。……