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重症监护病房铜绿假单胞菌感染影响因素探究及耐药性分析

2017-02-27袁雕

中外医学研究 2016年34期
关键词:影响因素

袁雕

【摘要】 目的:探究重症监护病房铜绿假单胞菌感染的影响因素,并对其耐药性进行分析。方法:随机抽取2013年5月-2015年9月在笔者所在医院治疗的重症监护病房铜绿假单胞菌感染患者90例,观察患者感染的影响因素,并分析铜绿假单胞菌对药物的耐药性。结果:经对患者进行密切观察可发现对于ICU患者感染铜绿假单胞菌的影响因素主要为机械通气(OR=3.365,95%CI 1.408~8.043)、慢性阻塞性肺疾病(COPD)(OR=5.728,95%CI 2.643~12.424)、深静脉置管(OR=3. 591,95%CI 1.666~7.739);对于药物的耐药性研究表明:铜绿假单胞菌对于常用抗菌药物具有不同的耐药性表现,其对喹诺酮类药物耐药性最低,对头孢类及青霉素类药物的耐药性最高,而对于氨基酸苷类等其他抗菌药物的耐药性较适中。结论:铜绿假单胞菌感染对于重症监护病房内的患者为好发并发症,但其对于常见抗菌药物具有多重耐药性,医护人员应根据具体耐药情况选择相应的抗菌药物进行治疗,以便取得理想的临床治疗效果。

【关键词】 重症监护病房; 铜绿假单胞菌; 感染; 影响因素; 耐药性

doi:10.14033/j.cnki.cfmr.2016.34.026 文献标识码 B 文章编号 1674-6805(2016)34-0048-02

Analysis of Influencing Factors and Drug Resistance of Pseudomonas Aeruginosa Infection in Intensive Care Unit/YUAN Diao.//Chinese and Foreign Medical Research,2016,14(34):48-49

【Abstract】 Objective:To explore the influencing factors of ICU pseudomonas aeruginosa infection,and to analyze the drug resistance.Method:90 cases of patients with Pseudomonas aeruginosa infection came form intensive care in the authors hospital were Randomly chosen, the factors of patients with infection were observed and the Drug resistance of Pseudomonas aeruginosa were analysised.Result:The patients were observed closely can be found for ICU patients infected with Pseudomonas aeruginosa factors mainly was mechanical ventilation (OR=3.365,95%CI 1.408-8.043) and chronic obstructive pulmonary disease (COPD) (OR=5.728,95%CI 2.643-12.424),deep vein set tube (OR=3.591,95%CI 1.666-7.739).For the study of drug resistance showed that Pseudomonas aeruginosa to commonly used antimicrobial agents with different resistance performance,the quinolone resistance of the lowest of cephalosporins and penicillins drug resistance was the highest, and the amino acid glycosides and other antimicrobial drug resistance were moderate.Conclusion:Pseudomonas aeruginosabacteria infection for ICU patients occurred complications,but the to common antimicrobial agents with multiple Heavy resistance,health care workers should be based on specific drug resistance to select the appropriate antimicrobial agents for treatment,in order to achieve the desired results of clinical treatment.

【Key words】 Intensive care unit; Pseudomonas aeruginosa; Infection; Influencing factors; Drug resistance

First-authors address: Wenshan Peoples Hospital,Wenshan 663000,China

重癥监护室内的患者因病情危重,住院时间久,自身机体免疫力严重下降,治疗过程中患者需长时间使用广谱的抗菌药物,同时经历多种侵入性操作,极易感染多种病菌[1]。铜绿假单胞菌广泛分布于自然界中,是一种革兰氏阴性菌,常见于条件致病菌,因其极易产生细菌生物被膜,因此临床治愈率较低,治愈难度较大,患者致死率较高,容易并发呼吸道及泌尿道等系统的感染,在医院感染中占60%以上[2]。……

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