王颖

摘要：目的：保肾片中苍术挥发油的最佳包合工艺及其包合物的稳定性考察。方法：采用正交设计，以挥发油包合率为考察指标优选包合工艺。以苍术素为考察指标，对包合物进行强光照射、高温和高湿等稳定性考察。结果：苍术挥发油的最佳包合工艺为：研磨时间30 min，包合温度30℃，苍术挥发油：β-环糊精为1：8，β-环糊精：纯化水为1：2；在强光、高热、高湿等因素影响下，包合物中苍术素含量没有明显变化。结论：该包合工艺稳定，包合物质量可控。

Abstract： Objective：To optimize the inclusion technology of β-cyclodextrin （β-CD） with volatile oil from Atractylodes lancea in Baoshen Tablets. And to observe the stability of the inclusion compounds. Methods：The orthogonal design was used to optimize the inclusion technology and the inclusion ratio of volatile oil was used as the criteria. The stability test was observed under the condition of intense light， high temperature and humidity with atractylodin as the index. Results：The optimum inclusion conditions were established as follows∶ the inclusion temperature was 30℃ and time was 30min， the ratio of volatile oil to β-CD was 1∶8， and the ratio of β-CD to water was 1∶2. The stability test showed the content of atractylodin has no significant difference. Conclusion：The optimized conclusion technology is stable and the quality of compounds can be controled.

关键词：苍术素；β-CD；包合物；稳定性

Key words： atractylodin；β-cyclodextrin；inclusion compounds；stability

中圖分类号：TQ461 文献标识码：A 文章编号：1006-4311（2017）04-0112-03

0 引言

苍术为菊科植物北苍术的干燥根茎，具有燥湿健脾、祛风散寒、明目之功效，用于风寒感冒、风湿痹痛、水肿、夜盲、脘腹胀满、泄泻、脚气痿痹等病症的缓解与治疗。[1]具有中枢神经抑制、抗病毒、抗胃溃疡、抗缺氧等功效挥发油[2，3]是苍术中一味重要的活性成分。但是这种成分在光、热作用下易挥发，性能不稳定，放置时间越长越容易变质[4-6]。β-环糊精包合中药挥发油可以阻断其与光热的接触，使其保持稳定性能，目前这种方法已在中药制剂领域广泛传播[7-10]。本实验采用正交设计刷选挥发油的最佳包合工艺，并首次对工艺的稳定性进行了研究。

1 实验材料

实验所用仪器、试药详见表1。

2 方法与结果

2.1 苍术挥发油的提取

用蒸汽从适量苍术（制）饮片中提取挥发油[9]，密封存放在棕色试剂瓶中备用。

2.2 苍术挥发油β-CD包合工艺

2.2.1 制备包合物

按照配比要求称量出一定量电费……