曹智丽++++++车建斌++++++张文双++++++王艳++++++王维

[摘要] 目的 观察多烯磷脂酰胆碱、丹参酮ⅡA磺酸钠注射液二者联合用于酒精性肝硬化治疗中的临床效果。 方法 选择2013年10月～2015年10月河北北方学院附属第二医院消化科及感染科收治的酒精性肝硬化患者56例，根据随机数字表法分为对照组和观察组，每组各28例。所有患者均予绝对戒酒及基础支持治疗，对照组给予丹参酮ⅡA磺酸钠注射液，观察组给予多烯磷脂酰胆碱联合丹参酮ⅡA磺酸钠注射液治疗，疗程均为4周。比较两组疗效；比较两组患者治疗前后天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、总胆红素（TBIL）、碱性磷酸酶（ALP）、γ-谷氨酰转肽酶（γ-GT）、凝血酶原时间（PT），及白蛋白（ALB）水平。 结果 治疗前，两组患者的肝功能指标TBIL、ALT、AST、ALP、γ-GT、ALB及PT比较，差异无统计学意义（P > 0.05）。治疗后，两组患者的肝功能指标TBIL、ALT、AST、ALP、γ-GT均较治疗前显著降低，ALB及PT较治疗前显著升高，且观察组患者的TBIL、ALT、AST、ALP、γ-GT显著低于对照组，ALB、PT显著高于对照组，差异均有统计学意义（P < 0.05）。 结论 多烯磷脂酰胆碱、丹参酮ⅡA磺酸钠注射液二者联合用于酒精性肝硬化治疗中临床效果确切，且肝功能明显改善，二者联合应用有较好的协同作用，值得推广和应用。

[关键词] 多烯磷脂酰胆碱；丹参酮ⅡA磺酸钠注射液；酒精性肝硬化；肝功能

[中图分类号] R657.31 [文献标识码] A [文章编号] 1674-4721（2016）09（a）-0055-04

[Abstract] Objective To observe the clinical effect of the combination of Polyene Phosphatidyl Choline and Tanshinone ⅡA Sulfonate Sodium Injection in the treatment of alcoholic liver cirrhosis. Methods From October 2013 to October 2015， 56 patients with alcoholic liver cirrhosis in the Department of Gastroenterology and infectious diseases of the Second Affiliated Hospital of Hebei North University were selected， according to the random number table method they were randomly divided into control group and observation group， with 28 cases in each group. All patients were treated with absolute alcohol and basic supportive therapy， and Tanshinone ⅡA Sulfonate Sodium Injection was given to the control group， the observation group was given Polyene Phosphatidyl Choline combined with Tanshinone ⅡA Sulfonate Sodium Injection， a course of 4 weeks. The curative effect of the two groups was compared； levels of the aspartate aminotransferase （AST）， alanine amino transfer enzyme （ALT）， total bilirubin （TBIL）， alkaline phosphatase （ALP） and R Valley aminoacyl transfer peptidase （γ-GT） and prothrombin time （PT）， albumin （ALB） of patients in the two groups before and after treatment were compared. Results Before treatment， the liver function indexes of TBIL， ALT， AST， ALP， ALB， γ-GT and PT between two groups showed no statistically significant difference （P > 0.05）. After treatment， TBIL， ALT， AST， ALP， GGT of the two groups were significantly lower compared with those before treatment， ALB and PT were significantly increased compared with those before treatment， TBIL， ALT， AST， ALP， GGT of patients in the observation group were significantly lower than those of the control group， ALB and PT were significantly higher than those of the control group， the differences were statistically significant （P < 0.05）. Conclusion Polyene Phosphatidyl Choline combined with Tanshinone ⅡA Sulfonate Sodium Injection in the treatment of alcoholic liver cirrhosis has exact clinical curative effect， it can improve the liver function， combination of the two drugs have good synergistic effect， worthy of promotion and application.

[Key words] Polyene Phosphatidyl Choline； Tanshinone ⅡA Sulfonate Sodium Injection； Alcoholic liver cirrhosis； Liver function

近年来，由于长期大量饮酒导致的酒精性肝病（Alcoholic liver disease，ALD）的发病率逐年增加，酒精性肝病已经成为世界范围内慢性肝病之一，尤其是在发达国家，如英国、美国等，且日趋年轻化[1]。酒精性肝病是临床的常见病、多发病，目前主要包括酒精性脂肪肝、酒精性肝炎、酒精性肝纤维化、酒精性肝硬化和肝细胞癌等[2]。酒精性肝硬化是酒精性肝病程度较严重的一种类型，主要是由于长期过量饮酒导致的肝细胞中的脂肪变性坏死，肝细胞纤维化，最终导致肝细胞硬化[3]。酒……