王 彤，张昆艳，张建丽

(河北省唐山市妇幼保健院新生儿科，唐山 063000)



维生素A联合重组人促红细胞生成素预防早产儿贫血的疗效

王 彤，张昆艳，张建丽

(河北省唐山市妇幼保健院新生儿科，唐山 063000)

目的 在给予重组人促红细胞生成素的基础上，观察口服维生素A预防早产儿贫血的效果。方法 选取120例早产儿，分成3组，对照组给予常规治疗，观察A组给予重组人促红细胞生成素(rHu-EPO)及维生素D滴剂，观察B组给予重组人促红细胞生成素及维生素AD滴剂。3组患儿均在出生后第14天开始给予维生素E、赖氨肌醇维生素B12及依地酸铁钠口服溶液，疗程共4周；对比3组早产儿治疗前后体质量、血红蛋白(Hb)、红细胞比容(Hct)、血清铁蛋白(SF)及网织红细胞(Ret)的变化情况，统计其输血例数。结果 治疗后，患儿Hb、Hct、Ret水平及输血例数各组间均有显著差异(P<0.05)；其SF水平观察B组高于观察A组及对照组(P<0.05)，观察A组与对照组无显著差异；观察组W水平显著高于对照组(P<0.05)，但观察A组及B组间差异不明显。结论 在给予重组人促红细胞生成素的基础上加用维生素A能有效地预防早产儿贫血。

维生素A；重组人促红细胞生成素；早产儿；贫血

A.stract:Objective To observe the effect of vitamin A combined with recombinant human erythropoietin on the prevention of the anemia of prematurity.Methods Totally 120 premature infants who were born in our hospital were randomly divided into 3 groups according to voluntary principle of parents.Babies in all groups were given vitamin E,lysine，inosite and vitamin B12Oral Solution，Ferric Sodium Edentate Oral Solution when they were 14 days old，and the treatment course was 4 weeks.The observation group A were treated with recombinant human erythropoietin and vitamin D.The observation group B were treated with recombinant human erythropoietin and vitamin AD.The weight(W)，hemoglobin(Hb)，hematocrit(HCT)，serum iron (SF) reticulocyte(Ret) and blood transfusion cases were observed and recorded at the beginning and the end of the treatment.Results After treatment，Hb，HCT、Ret and blood transfusion cases were significantly different among the groups(P<0.05)；SF in the observation group B was significantly high compared with the other 2 groups，but no significant difference between the observation group A and the control group(P<0.05)；W in the observation group was significantly higher than that in the control group(P<0.05)，but no significant difference between the observation group A and the observation group B.Conclusion Vitamin A combined with recombinant human erythropoietin can effectively control the anemia of prematurity.

贫血是早产儿易出现的并发症，尤其是胎龄偏小、体质量偏轻的早产儿，出现的时间更早、病情更重[1]。我国早产儿出生率达8.1%[2]。在各种原因住院的早产儿中，出生后贫血发生率约在40%左右[3]。造成存活早产儿贫血的原因较多，除疾病所致的贫血外，各种营养物质的缺乏造成的营养性贫血最为多见。本文旨在研究在给予重组人促红细胞生成素的基础上加用维生素A预防早产儿贫血的效果。

1 资料与方法

1.1 一般资料 选取2014年6月～12月在我院出生的120例存活的早产儿作为研究对象，其中男婴52例，女婴68例；胎龄28～36周，平均胎龄33.4±2.7周；……