血脂和尿酸检测对视网膜静脉阻塞患者的意义
2016-11-09赖海燕李品霞张义彪
赖海燕+李品霞+张义彪


摘 要 目的:观察视网膜静脉阻塞(RVO)患者血脂4项和尿酸含量的变化,以探讨RVO与血脂和尿酸的相关性。方法:采用病例对照研究,本院确诊RVO患者58例和同期健康体检者50例,测定两组血脂4项和尿酸水平。结果:RVO患者尿酸和胆固醇(CHOL)、甘油三酯(TG)、低密度脂蛋白 (LDL-C) 水平均较健康对照组明显升高,两组比较差异有统计学意义(P<0.05),高密度脂蛋白(HDL-C)水平较健康对照组明显降低,两组比较差异有统计学意义(P<0.05)。结论:高尿酸血症和高脂血症是RVO的危险因素,防治RVO需控制尿酸和血脂水平。
关键词 视网膜静脉阻塞 血脂 尿酸 危险因素
中图分类号:R774.5 文献标识码:B 文章编号:1006-1533(2016)19-0048-03
Significance of the determination of blood lipids and uric acid to patients with retinal vein occlusion
LAI Haiyan1, LI Pinxia1, ZHANG Yibiao2(1.Department of Clinical Laboratory, The Third Peoples Hospital of Zhangjiagang City, Zhangjiagang 215611, China;2. Department of Ophthalmology, The Third peoples Hospital of Zhangjiagang City, Zhangjiagang 215611, China)
ABSTRACT Objective: To observe the blood lipid four items and the change of uric acid contents in patients with retinal vein occlusion (RVO) so as to investigate the relationship between RVO and blood lipids and uric acid. Methods: Fifty-eight patients with RVO and 50 cases of healthy subjects were selected based on case-control study and their blood lipid four items and uric acid levels were determined. Results: The levels of uric acid and cholesterol (CHOL), triglyceride (TG) and low density lipoprotein (LDL-C) were significantly higher while the levels of high density lipoprotein (HDL-C) were significantly lower in patients with RVO than in healthy subjects (P<0.05). Conclusion: Hyperuricemia and hyperlipidemia are the risk factors of RVO and the levels of blood uric acid and lipids should be controlled when RVO has to be prevented and controlled.
KEY WORDS retinal vein occlusion; blood lipid; uric acid; risk factors
视网膜静脉阻塞(retinal vein occlusion, RVO)是仅次于糖尿病性视网膜病变的临床常见的视网膜血管病变,以静脉迂曲扩张,视网膜出血及黄斑囊样水肿、渗出等为主要眼底表现。发病急,病程冗长,视力严重下降,往往因并发黄斑囊样水肿及新生血管性青光眼等而失明[1]。为探讨RVO与尿酸和血脂的关系,本文观察了RVO患者血脂4项和尿酸含量的变化,现将结果报告如下。
1 资料与方法
1.1 资料来源
选择2010年4月—2015年3月我院眼科诊断为RVO的患者58例,其中男23 例,女35 例,年龄30~80岁,平均年龄60.28岁,其中视网膜中央静脉阻塞 (centrel retinal vein obstruction,CRVO)患者22例,视网膜分支静脉阻塞(branch retinal vein occlusion,BRVO)患者36例,均排除糖尿病、心血管疾病、肝肾功能不全和眼外伤等疾病。对照组选择我院同期健康体检者50例,其中男39 例,女 11例,年龄29~84岁,平均年龄61岁,排除心血管疾病、肝肾等实质性病变及出血、血栓性疾病,眼底血管性病史等。两组患者在年龄、性别等基本资料上无统计学差异,具可比性。本试验通过院医学伦理委员会批准,所有研究对象均签署知情同意书。……
