杨芸　周渊

【摘要】 目的：观察沙丁胺醇雾化吸入应用于哮喘急性发作的临床价值。方法：2012年10月-2014年4月笔者所在医院确诊并收治的164例支气管哮喘患者按照随机数字表法分为研究组和对照组，每组82例。全部患者给予低流量吸氧、止咳化痰、抗感染、营养支持等基础治疗。对照组在基础治疗的同时接受溴化异丙托品雾化吸入治疗。研究组将溴化异丙托品500 μg及沙丁胺醇2.5 mg+2.5 ml生理盐水中实施雾化吸入。两组均治疗10 d。治疗结束后对比两组疗效、治疗前后哮喘症状评分、治疗前后肺功能指标。结果：研究组的总有效率为93.90%，对照组总有效率为80.49%，研究组总有效率显著優于对照组（P<0.05）。治疗前两组白天和夜间哮喘症状评分比较差异无统计学意义（P>0.05），治疗后均比治疗前显著改善（P<0.05），研究组改善幅度显著优于对照组（P<0.05）。两组治疗前的用力肺活量、1秒用力呼气容积及呼气流速峰值比较差异无统计学意义（P>0.05），治疗后以上指标较治疗前大幅度好转（P<0.05），研究组这些指标好转幅度显著大于对照组（P<0.05）。结论：沙丁胺醇雾化吸入应用于哮喘急性发作可显著提升疗效，极大改善患者症状，促进肺功能恢复。

【关键词】 沙丁胺醇； 支气管哮喘； 肺功能

中图分类号 R562.2 文献标识码 A 文章编号 1674-6805（2016）6-0008-03

The Application of Aerosol Inhalation of Salbutamol in Acute Attack of Asthma/YANG Yun，ZHOU Yuan.//Chinese and Foreign Medical Research，2016，14（6）：8-10

【Abstract】 Objective：To observe the clinical effect of aerosol inhalation of Salbutamol in the acute attack of asthma.Method：164 patients with bronchial asthma diagnosed and treated in our hospital from October 2012 to April 2014 were divided into the research group and control one according to the random number table，with 82 cases in each group.All patients received the basic treatments of low-flow oxygen inhalation，cough-relieving and sputum-reducing，anti-injection and nutritional support.In addition to the basic treatments，patients in the control group received the aerosol inhalation of Ipratropium Bromide.Patients in the research group received the aerosol inhalation of 500μg Ipratropium Bromide and 2.5 mg Salbutamol in 2.5 ml Normal Saline.The duration of treatment for both groups was all 10 d.The curative effect after the treatment，asthma score before and after the treatment and pulmonary function indicator before and after the treatment were compared between two groups.Result：The overall response rate of the research group was 93.90%，which was significantly better than 80.49% of the control group（P<0.05）.There was no significant difference in the asthma score day and night before the treatment between two groups（P>0.05），but they were significantly improved after the treatment（P<0.05），where the improvement for patients in the research group was significantly better than the one in the control group（P<0.05）.There was no significant difference in the forced vital capacity，forced expiratory volume in one second and peak expiratory flow rate before the treatment between two groups（P>0.05），but these above indicators were significantly improved after the treatment（P<0.05），where the improvement for patients in the research group was significantly better than the one in the control group（P<0.05）.Conclusion：The aerosol inhalation of Salbutamol in the acute attack of asthma can significantly promote the curative effect，greatly improve the patients symptoms and enhance the recovery of pulmonary function.

【Key words】 Salbutamol； Bronchial asthma； Pulmonary function

First-authors address：Central Peoples Hospital of Neijiang City，Neijiang 641000，China

doi：10.14033/j.cnki.cfmr.2016.6.004

在临床上，支气管哮喘是呼吸内科的常见病和多发病，而随着慢性阻塞性肺疾病的进程加剧，支气管哮喘起到了重要的转折性病理标记作用。支气管哮喘承接着慢性支气管炎与肺气肿，是慢性阻塞性肺疾病起初的单纯非特异性炎症病变转化至中后期肺通气功能广泛受损的承接性病变特征。因而，支气管哮喘兼具非特异性炎症与气道高反应通气障碍两种病理特性。本病患者以咳、痰、喘、胸闷、呼吸困难为主要表现[1]，且夜间或情志、环境显著变化时可加剧，甚至进入急性发作期[2]。本病急性发作期患者其病情进展迅速，故必须第一时间得到临床治疗和控制。……