于 倩

老年高血压患者血清尿酸水平与颈动脉粥样硬化的关系

于 倩

目的 探讨老年高血压患者血清尿酸水平与颈动脉粥样硬化的相关性。方法 选取辽宁省人民医院2013年12月至2015年3月收治的93例老年高血压患者为研究对象，根据彩超颈动脉内膜中层厚度（IMT）测定结果进行分组，颈动脉粥样硬化患者51例为A组，颈动脉正常患者42例为B组。两组患者分别进行总胆固醇、体重指数、收缩压、舒张压、尿酸、肌酐等指标的比较，观察其与颈动脉IMT的相关性。结果 A组患者收缩压、总胆固醇、尿酸水平均明显高于B组，差异均有统计学意义（均P＜0.05）。以患者体重指数、收缩压、舒张压、总胆固醇、肌酐、尿酸等作为自变量，颈动脉IMT为应变量，结果显示，颈动脉IMT与尿酸呈正相关性（r=0.423，P＜0.05）。结论 血清尿酸水平是老年高血压患者动脉粥样硬化形成的独立危险因素，因此，临床对于高血压合并高尿酸血症患者需要加以重视，及时控制病情发展，对降低心脑血管疾病发生具有积极意义。

颈动脉粥样硬化；老年高血压；血清尿酸；相关性

【Abstract】Objective To investigate the correlation between serum uric acid level and carotid artery atherosclerosis in elderly patients with hypertension.Methods Select the Liaoning Provincial People's Hospital on 12 May 2013 to March 2015 were treated 93 cases of elderly hypertensive patients for the study，based on ultrasound carotid intima-media thickness （IMT） measurement results are grouped carotid atherosclerosis 51 patients group a，patients with normal carotid artery 42 cases of group B.Two groups of patients were total cholesterol，more body mass index，systolic blood pressure，diastolic blood pressure， uric acid，creatinine and other indicators observed with carotid IMT correlation.Results A group of patients with systolic blood pressure，total cholesterol， uric acid levels were significantly higher than group B，the differences were statistically significant （P＜0.05）.In patients with a body mass index，systolic blood pressure，diastolic blood pressure，total cholesterol，creatinine，uric acid as an independent variable，carotid IMT as dependent variable showed that carotid IMT and uric acid was positively correlated （r=0.423，P＜0.05）.Conclusion Serum uric acid level and carotid artery MIT in elderly patients with hypertension are positively correlated，which can be used as the main indicators of prognosis.

【Key words】Carotid atherosclerosis；Elderly patients with hypertension；Serum uric acid；Correlation

高血压为发病率最高的慢性非传染性疾病，为引发动脉粥样硬化的主要危险因素。心脑血管疾病大多发病于动脉粥样硬化基础之上。因此，早期发现及预防动脉粥样硬化，对降低心脑血管疾病的发生具有重要意义［1］。有学者认为［2］，高尿酸血症是引发动脉粥样硬化形成重要因素，会加速动脉粥样硬化发展，加重心血管病变。本研究对老年高血压患者测定血清尿酸水平，判断其与动脉粥样硬化相关性，现报道如下。……