马晓伟

药物治疗配合开喉剑喷剂治疗小儿疱疹性口腔炎的临床疗效

马晓伟

目的 探讨疱疹性口腔炎患儿合用开喉剑喷剂与药物治疗的临床适用性及安全性。方法 选取2013年8月至2015年8月沈阳市儿童医院收治的疱疹性口腔炎患儿70例为研究对象，按随机数字表法分为观察组和对照组，每组35例。对照组患儿接受常规药物治疗，观察组患儿在药物治疗的基础上接受开喉剑喷剂治疗，治疗1个疗程后，比较两组治疗的适用性及安全性。结果 观察组患儿的治疗总有效率为94.3%，较对照组的74.3%显著提高，差异有统计学意义（P＜0.05）。观察组患儿的体温正常时间为（2.1±1.2）d，口腔疱疹消退时间为（5.8±1.3）d，平均住院时间为（6.9±1.5）d，均较对照组显著缩短，差异均有统计学意义（均P＜0.05）。两组患儿在治疗期间均未发生严重不良反应。结论 合用药物与开喉剑喷剂治疗小儿疱疹性口腔炎疗效显著，安全性高，且有利于患儿症状的早日恢复。

疱疹性口腔炎；开喉剑喷剂；药物治疗；适用性；安全性；儿童；治疗效果

【Abstract】Objective To discuss the clinical applicability and safety of the treatment of Infantile herpetic stomatitis treated with drug therapy and Kaihoujian spray.Methods Select August 2013 to August 2015， Shenyang Children's Hospital of herpetic stomatitis in children with 70 cases for the study， were randomly divided into observation group and control group 35 cases. Children in the control group received conventional therapy， patients in the observation group accepted the sword open throat spray treatment on the basis of drug treatment， after treatment， a course of treatment were compared applicability and safety.Results Treatment of children with the observation group total effective rate was 94.3%， compared with 74.3% in the control group significantly increased， the difference was statistically significant（P＜0.05）.Observation of children with normal body temperature set time （2.1±1.2） d， oral herpes subsided time was （5.8±1.3） d， the average hospital stay was （6.9±1.5） d， compared with the control group significantly reduced， the difference was statistical significance（P＜0.05）. Two groups of children with serious adverse events did not occur during treatment.Conclusion If the patients with Infantile herpetic stomatitis are treated with drug therapy and Kaihoujian，the curative effect are safe and ideal，conducive to the speedy recovery of，and worth promoting.

【Key words】Infantile herpetic stomatitis；Kaihoujian spray；Drug therapy；Applicability；Security；Children；Therapeutic effect

疱疹性口腔炎是一种小儿常见病，一般是因单纯疱疹病毒Ⅰ型感染引起，患儿感染后往往口唇、牙龈及颊黏膜等部位发病，也有少数见于舌体与软腭［1］。疱疹性口腔炎会引起患儿口腔疼痛、流涎、发热等临床表现，还可能导致患儿发生脱水或酸中毒，对患儿的健康危害极大［2］。本病多见于6个月至5岁婴幼儿，任何季节均可以发生［3］。单纯疱疹病毒Ⅰ型通常经呼吸道、口腔等途径传播，有较强的传染性，一旦患病，往往需要接受全身对症治疗和抗感染治疗［4］，采取中西医结合治疗可以达到标本兼顾、促进症状缓解、使机体早日恢复的目的。……