郭淑玲

抗氧化剂联合鲑鱼降钙素治疗糖尿病性骨质疏松患者的临床疗效

郭淑玲

目的 探讨抗氧化剂联合鲑鱼降钙素治疗糖尿病性骨质疏松患者的临床疗效。方法 选取2013年1月至2015年1月临汾市骨科医院收治的121例糖尿病性骨质疏松患者作为研究对象，采用随机数字表法将其分为对照组（60例）与观察组（61例）。对照组患者肌内注射鲑鱼降钙素注射液，同时口服碳酸钙D3片，观察组患者在对照组基础上采用抗氧化剂硫辛酸进行治疗，比较两组患者治疗前后骨代谢及骨转化情况、血糖及疼痛程度、自我效能量表评分。结果 治疗后，观察组患者的Ⅰ型胶原交联羧基末端肽（CTX-1）明显低于对照组，碱性磷酸酶（ALP）、骨钙素（BGP）均明显高于对照组，差异均有统计学意义（均P＜0.05）；治疗后，观察组患者的空腹血糖（FBG）、餐后2 h血糖（2hPBG）及疼痛视觉模拟量表（VAS）评分均明显低于对照组，差异均有统计学意义（均P＜0.05）；治疗后，观察组患者的运动效能、摄钙效能评分及总分均明显高于对照组，差异均有统计学意义（均P＜0.05）。结论 在抗氧化治疗基础上应用鲑鱼降钙素可有效改善糖尿病性骨质疏松患者骨代谢，减轻疼痛，血糖控制效果理想，是提高临床疗效的重要方法。

糖尿病；骨质疏松；抗氧化；鲑鱼降钙素

【Abstract】Objective To investigate the clinical effect of anti oxidants combined with salmon calcitonin in the treatment of diabetic osteoporosis patients.Methods From January 2013 to January 2015，121 patients with diabetic osteoporosis were treated in the Department of orthopedics of Linfen city as the research object，and were randomly divided into control group（60 cases） and observation group （61 cases）.Control group patients with intramuscular injection of salmon calcitonin injection，and oral calcium carbonate D3 tablets were observed group of patients in the control group on the basis of the antioxidants lipoic acid treatment，were compared between the two groups before and after treatment in patients with bone metabolism and bone transformation，the blood glucose and the degree of pain，self-efficacy energy scale.Results After treatment，the observation group of patients with type I collagen cross-linked carboxy terminal peptide（CTX-1） was significantly lower than that of the control group，alkaline phosphatase（ALP），bone gla protein（BGP） were significantly higher than that of the control group，the differences were statistically significant（P＜0.05）；treatment，the observation group of patients with fasting blood glucose（FBG），postprandial 2 h blood glucose （2hPBG） and pain visual analogue scale（VAS） scores were significantly lower than those of the control group，the differences were statistically significant（P＜0.05）；treatment，the observation group of patients with movement efficiency，Ca2+uptake efficiency score and total score were significantly higher than that of the control group，the differences were statistically significant（P＜0.05）.Conclusion Application of salmon calcitonin in the treatment of anti oxidative treatment can effectively improve the bone metabolism，reduce the pain and the effect of blood glucose control in diabetic osteoporosis patients.It is an important method to improve the clinical efficacy.

【Key words】Diabetes；Osteoporosis；Antioxidant；Salmon calcitonin

随着饮食结构的改变及老龄化加速，在我国糖尿病的发病率呈增高趋势。机体长期处于高血糖状态，葡萄糖从尿中排出的同时，可因渗透性利尿作用促进钙离子流失，间接刺激甲状旁腺素分泌［1］。……