唐　瑶， 何　丽， 李珏杉

(成都市妇女儿童中心医院 妇科， 四川 成都　610000)



半乳凝素-3在宫颈上皮瘤变和宫颈鳞状细胞癌中的表达

唐瑶， 何丽， 李珏杉

(成都市妇女儿童中心医院 妇科， 四川 成都610000)

目的： 探讨半乳凝素-3(Galectin-3)在宫颈上皮瘤变(CIN)、宫颈鳞状细胞癌组织中的表达及其意义。方法： 选择80例宫颈鳞状细胞癌组织标本、60例CIN标本及20例正常宫颈组织标本作为研究对象，采用免疫组化法检测组织中Galectin-3蛋白表达，观察不同CIN分级及宫颈鳞状细胞癌患者的分化程度、病灶大小、是否发生淋巴转移、年龄及临床分期与Galectin-3蛋白阳性表达率的关系。结果： 3组Galectin-3蛋白阳性表达率比较，宫颈鳞状细胞癌组织中显著高于CIN和正常宫颈组织(P<0.05)，CIN组织和正常宫颈组织差异无统计学意义(P>0.05)；不同CIN分级患者组织中Galectin-3蛋白阳性表达率比较，差异无统计学意义(P>0.05)；宫颈鳞癌组织中Galectin-3蛋白阳性表达率在低分化、病灶≥2cm及癌细胞未发生淋巴转移患者中显著升高，差异有统计学意义(P<0.05)；在不同年龄和不同临床分期患者间比较，差异无统计学意义(P>0.05)。结论： 宫颈鳞癌组织中Galectin-3蛋白阳性表达率显著增高，与患者的癌细胞的分化程度、病灶大小及淋巴结转移有关。

半乳凝素-3； 宫颈上皮瘤变； 宫颈鳞状细胞癌； 免疫组织化学； 淋巴转移； 肿瘤分期

[Abstract]Objective: To investigate the expression and significance of -3 (Galectin-3) in cervical squamous cell carcinoma (CIN) and cervical squamous cell carcinoma (SCC). Methods： 80 cases of cervical squamous cell carcinoma tissue specimens and 60 cases of CIN tissues, 20 cases of normal cervical tissue specimens were collected, using immunohistochemical method to detect the expressive intensity of galectin-3 in three groups, and analyzing galectin-3 protein and cervical squamous cell carcinoma patients clinical pathological features. Results: In squamous cell carcinoma of cervix galectin-3 protein positive expression rate was 82.50% significantly than 31.67% in CIN tissues and normal cervical tissues of 35.00%, the difference has statistical significance (P<0.05); normal cervical tissue and CIN and galectin-3 protein positive expression rate differences had no statistical significance (P>0.05). Cervical squamous cell carcinoma in galectin-3 protein positive expression rate in patients with different degree of differentiation, tumor size, whether lymph node metastasis has a statistically significant relationship (P<0.05), and the age of patients, the clinical staging was not significant (P>0.05). Conclusion: The positive expression rate of Galectin-3 protein in cervical squamous cell carcinoma was significantly increased, and it had a certain relationship with the degree of differentiation, the size of the lesion and lymph node metastasis.

[Key words]Galectin-3; cervical intraepithelial neoplasia; cervical squamous cell carcinoma; immunohistochemistry; lymphnode metastasis; tumor stage

宫颈癌以及宫颈上皮内瘤变(cervical intraepithelial neoplasia，CIN)是宫颈细胞长期病变的结果，大多学者认为宫颈上皮HPV病毒感染是导致CIN及宫颈原位癌连续性病变的主要因素，但近年来的研究发现，单纯的HPV感染不足以导致宫颈原位癌或者浸润型癌的发生[1-2]。有学者提出细胞增殖周期调节、代谢以及细胞生理特征调控可……