任宏涛　王中卫　王宝锋　王亚利　黄珊　王西京

[摘 要] 目的：分析西妥昔单抗及氟尿嘧啶对大肠癌细胞放疗敏感性影响。方法：选取我院2011年3月—2013年3月收治的100例大肠癌患者，随机数字表法分为单纯放疗组（A组）、西妥昔单抗联合放疗组（B组）、氟尿嘧啶联合放疗组（C组）、西妥昔单抗及氟尿嘧啶联合放疗组（D组），各25例，按照患者组别给予相应治疗，行大肠癌根治术。比较各组患者病理完全缓解（Pathological complete response，pCR）率及2年生存率、复发率，总结西妥昔单抗及氟尿嘧啶对大肠癌细胞放疗敏感性的影响。结果：D组pCR率最高，为24.0%（6/25），但与C组的20.0%（5/25）比较，差异无统计学意义（P>0.05），D组、C组均高于A组的8.0%（2/25）和B组的12.0%（3/25），差异有统计学意义（P<0.05）。各组患者治疗期间毒性反应比较，差异无统计学意义（P>0.05）。D组、B组、C组复发率均为0，其2年DFS、OS均显著高于A组，差异有统计学意义（P<0.05）。结论：西妥昔单抗、氟尿嘧啶均可在一定程度上增强大肠癌细胞放疗敏感性，氟尿嘧啶增敏效果更为显著，两药联合应用并不比氟尿嘧啶单药增敏效果显著。

[关键词] 西妥昔单抗；氟尿嘧啶；大肠癌；放疗；敏感性

中图分类号：R735.3 文献标识码：B 文章编号：2095-5200（2016）04-033-04

DOI：10.11876/mimt201604013

Impact of cetuximab combined with fluorouracil on radiation sensitivity of colorectal carcinoma REN Hongtao，WANG Zhongwei，WANG Baofeng，WANG Yali，HUANG Shan，WANG Xijing. （Department of Oncology，The Second Affiliated Hospital of Xian Jiaotong University，Xian 710004，China）

[Abstract] Objective： To analyze the influence of cetuximab with fluorouracil on radiation sensitivity of colorectal carcinoma. Methods： 100 cases of colorectal cancer patients admitted in our hospital from March 2011 to March 2013 were enrolled for the study. According to random number table， they were randomly divided into radiotherapy （group A）， cetuximab plus radiotherapy group （group B）， fluorouracil radiotherapy group （group C）， fluorouracil combined with cetuximab radiotherapy group （group D）， each 25 cases； the patients were treated in accordance with the different groups， conducted with colorectal cancer surgery. Rate of pathological complete response （pCR）， 2-year survival rate， recurrence rate were compared among all the groups of patients， the influence of cetuximab with fluorouracil on radiation sensitivity of colorectal carcinoma was analyzed. Results： The pCR rate of group D was 24.0% （6/25） which was highest， but the difference was not statistically significant compared with 20.0% （5/25） of group C （P>0.05）； pCR rate of group C and group D were both higher than group A 8.0% （2/25） and group B 12.0% （3/25）， the differences were statistically significant （P<0.05）. Toxic reaction during the treatment of patients in each group were compared， the differences were not statistically significant （P>0.05）. Recurrence rates of group D， group B， and group C were all 0， of which the 2-year DFS and OS were all significantly higher than those of group A， the difference were statistically significant （P<0.05）. Conclusions： Both of cetuximab and fluorouracil can be found to increase radiation sensitivity of colorectal cancer cell， sensitizing effect of fluorouracil is more significant， but the sensitizing effect of combination of the two kinds of drugs is not significant than that of fluorouracil.

[Key words] cetuximab；fluorouracil；colorectal cancer；radiotherapy；sensitivity

大肠癌包括结肠癌和直肠癌，其发病率仅次于胃癌、食管癌[1]。目前大肠癌的临床治疗以外科手术为主，多学科综合治疗在提高总体治疗效果中的作用已经得到公认[2]。实体肿瘤中普遍存在乏氧细胞，故放疗增敏尤其重要[3]。增加乏氧细胞对放射的敏感性不只是加大放疗剂量，放疗和化疗药物联合应用亦可有效提高大肠癌细胞放疗敏感性，提高患者病理完全缓解率（pCR率）。我院对应用西妥昔单抗、氟尿嘧啶单药及两药联合应用对大肠癌患者的放疗增敏作用进行对比研究，报道如下。

1 资料与方法

1.1 病例资料

选取我院2011年3月—2013年3月收治的100例大肠癌患者，按照随机数字表法分为单纯放疗组（A组）、西妥昔单抗联合放疗组（B组）、氟尿嘧啶联合放疗组（C组）、西妥昔单抗及氟尿嘧啶联合放疗组（D组），各25例。各……