杜锦辉郑皓云（.内蒙古医科大学附属医院，内蒙古 呼和浩特 00050；.内蒙古医科大学，内蒙古 呼和浩特 00050）

·实验报告·

蒙药如达溃疡散的急性毒性实验研究*

杜锦辉1郑皓云2
（1.内蒙古医科大学附属医院，内蒙古 呼和浩特 010050；2.内蒙古医科大学，内蒙古 呼和浩特 010050）

目的 观察蒙药如达溃疡散的急性毒性反应。方法 将12只昆明种小鼠随机分为两组，如达溃疡散组一次性灌胃最大质量浓度0.39 g/mL、最大体积0.8 mL；对照组予等体积蒸馏水。结果未测出如达溃疡散的半数致死量，改为最大耐受量试验。如达溃疡散高、中、低剂量组分别予0.39、0.26、0.13 g生药mL，最大给药体积0.8 mL；对照组予等体积蒸馏水，每天3次，间隔6 h，连续14 d，详细观察各组小鼠毒性反应和死亡情况。结果 个别小鼠给药后的前2 d出现大便呈黑褐色的现象，其他情况均正常，无死亡，解剖后观察小鼠主要内脏器官未见异常，各给药组与空白对照组的小鼠脏器指数、体质量均无显著差异（P＞0.05），小鼠最大给药量是46.8 g/kg，相当于临床人用剂量的468倍。结论 如达溃疡散急性毒性低，是一安全性较好的药物，临床使用量安全系数较高，按规定剂量口服安全可靠。

如达溃疡散 蒙药 急性毒性 小鼠

【Abstract】Objective：To observe the acute toxicity of Mongolian medicine radix ulcer powder reaction.Methods：Preliminary experiment：12 Kunming mice were randomly divided into two groups，Radix ulcer powder group with maximum concentration of drug 0.39 g/mL，the maximum volume of 0.8 mL，disposable to mice fed，the control group with an equal volume of distilled water.No median lethal dose of Radix ulcer powder was measured （LD50），changing into maximum tolerance test.High，medium and low dose groups were given 0.39，0.26，0.13 g/ mL，the maximum volume of 0.8 mL；the control group received an equal volume of distilled water three times a day，interval 6 hours with a continuous observation of 14d on detailed mice toxicity and death.Results：2 days after administration，there were some individual mice with dark brown stool phenomena，while other cases were normal，without a death.No abnormalities were found in the major organs of the mice after dissection.In the comparison of the control group and other groups，there was no significant difference in the mouse organ index and body mass（P＞0.05）.The maximum dose in mice is 46.8 g/kg，equivalent to 468 times the clinical human dose.Conclusion：Acute toxicity of Radix ulcer powder is low，and safety，the clinical use of high safety coefficient，the prescribed dose is safe to take.

【Key words】Radix ulcer powder；Mongolian medicine；Acute toxicity；Mice

蒙医学［1-3］认为胃溃疡的发生主要由于人体内的三根与七素的相对平衡遭到了破坏，巴达干偏盛，并同希拉、赫依相搏，引起胃火衰败，进而使功能紊乱，是一种胃腑的聚合性慢性疾病，可归蒙医学“胃包如病”范畴。名老蒙医都格尔扎布擅长消化系统疾病的诊治，认为治疗胃包如病应以祛巴达干为首，同时需护肝。……