左新河赵 勇陈继东裴 迅陈如泉（1.湖北省中医药大学，湖北 武汉 430061；.湖北省中医院，湖北 武汉 430061）

中药外敷治疗亚急性甲状腺炎疗效的Meta分析*

左新河1，2赵 勇2△陈继东2裴 迅2陈如泉1，2
（1.湖北省中医药大学，湖北 武汉 430061；2.湖北省中医院，湖北 武汉 430061）

目的 评价中药外敷治疗亚急性甲状腺炎的疗效及安全性。方法 计算机检索中国知网、维普期刊资源整合服务平台、万方数据库，查找中药外敷治疗亚急性甲状腺炎的的随机对照试验。由2名研究者独立对纳入研究进行资料提取和方法学质量评价，采用RevMan 5.2软件进行Meta分析。结果 共纳入13项研究，共1106例受试者。Meta分析结果显示，中药外敷与西药治疗的临床疗效比较，两组间差异具有统计学意义（P＜0.05）；中药外敷联合西药与西药治疗的临床疗效比较，两组间差异具有统计学意义（P＜0.01）；中药外敷联合中药口服与西药治疗的临床疗效比较，两组间差异具有统计学意义（P＜0.01），中药外敷联合中药口服及西药与西药治疗的临床疗效比较，两组间差异具有统计学意义（P＜0.05）。结论 中药外敷是治疗亚急性甲状腺炎的有效方法，尚需设计合理、执行严格、多中心、大样本的随机对照试验进一步验证。

中药外敷 亚急性甲状腺炎 内外合治 随机对照 Meta分析

【Abstract】Objective：To evaluate the effect and security of external application of Chinese herbal of subacute thyroiditis（SAT）.Methods：All randomized controlled trials（RCTs）of external application of Chinese herbal in treatment of SAT were collected from CNKI，VIP and WanFang，Embase with computer.After selection and data extraction by two researchers independently，researches quality was evaluated，and the data was analyzed with Revman 5.2 software software.Results：13 studies and 1106 patients were included.Results of Meta-analysis showed that there was statistically significant difference in clinical effect in the comparison between external application of Chinese herbal and Western medicine（P＜0.01）；there was statistically significant difference in clinical effect in the comparison between external application of Chinese herbal combined with oral Chinese medicine and only Western medicine；there was statistically significant difference in clinical effect in the comparison between external application of Chinese herbal combined with oral Chinese medicine and Western medicine and only Western medicine（P＜0.05）.Conclusion：External application of Chinese herbal plays a role in treating of SAT，but high quality researches need to be carried out for further research on the efficacy.

【Key words】External application of Chinese herbal；Subacute thyroiditis；Randomized

亚急性甲状腺炎（SAT）是最常见的甲状腺疼痛性疾病，以放射性痛和转移性痛为特征，伴有全身炎性反应。亚甲炎临床发病率约为4.9/10万，占甲状腺疾患的0.5～6.2%。其发病多认为由病毒感染或病毒感染后变态反应引发。西医治疗SAT多采用肾上腺皮质激素［1］。……