张遂峰 杨小军 田峰亮 罗 艳 谢慧民 廖小林 刘 薇 张 琼指导 王仁强（重庆市中医院，重庆 400021）

·研究报告·

疏肝健脾渗湿方治疗伴有焦虑、抑郁状态的胃食管反流病的临床研究*

张遂峰 杨小军 田峰亮 罗 艳 谢慧民 廖小林 刘 薇 张 琼△指导 王仁强
（重庆市中医院，重庆 400021）

目的 观察疏肝健脾渗湿方对伴焦虑、抑郁状态的急性加重期胃食管反流病的临床疗效。方法 将72例伴焦虑、抑郁状态的急性加重期胃食管反流病患者随机分为治疗组和对照组，各36例。治疗组以疏肝健脾渗湿方治疗，对照组以奥美拉唑镁肠溶片联合氟哌噻吨美利曲辛片治疗，疗程4周；通过观察焦虑自评量表、抑郁自评量表、反流性疾病问卷对两组患者进行疗效评估。结果 两组治疗前焦虑自评量表评分、抑郁自评量表评分、反流性疾病问卷（RDQ）积分比较，差异无显著性意义（P＞0.05）；治疗组总有效率为91.67%，对照组为88.89%，两组比较差异无统计学意义（P＞0.05）；两组治疗后焦虑、抑郁评分及治疗后3 d的RDQ评分与治疗前比较，差异均有统计学意义（P＜0.05）。结论 疏肝健脾渗湿方对急性加重期胃食管反流病治疗有效，并能改善为胃食管反流病患者的焦虑、抑郁状态。

疏肝健脾渗湿方 胃食管反流病 焦虑 抑郁

【Abstract】Objective：To observe the clinical effects of Shugan Jianpi Shenshi Decoction on acute exacerbation of gastroesophageal reflux disease（GERD）accompanied with anxiety and depression.Methods：72 cases were randomly divided into the control and the experimental groups，with 36 cases in each.The patients in the experimental group took Shugan Jianpi Shenshi Decoction，while patients in the control group received treatment of Omeprazole combined with flupentixol and melitracen tablets.4 weeks later，the clinical efficacies were assessed by Self-Rating Anxiety Scale（SAS），Self-Rating Depression Scale（SDS）and Reflux disease questionnaire（RDQ）.Results：Before treatment，there was no significant difference between the two groups（P＞0.05）.After treatment，the total effective rate was 91.67%in the experimental group and 88.89%in the control group with no significant difference between two groups（P＞0.05）.SAS，SDS and RDQ（3 days after treatment）were significantly different before and after trentment（P＜0.05）.Conclusion：Shugan Jianpi Shenshi Decoction is effective on acute exacerbation of gastroesophageal reflux disease，and can improve anxiety and depression state caused by gastroesophageal reflux disease.

【Key words】Shugan Jianpi Shenshi Decoction；Gastroesophageal reflux disease；Anxiety；Depression

胃食管反流病（GERD）是指胃、十二指肠内容物反流入食管引起的以烧心、反酸、胸骨后疼痛为主要临床症状的疾病。GERD的发病与食管抗反流屏障结构和功能异常、食管清除作用降低、食管黏膜屏障功能降低及情志因素有关，其中与焦虑、抑郁状态尤为密切［1-2］。……